Seroatlas · Human Serome Atlas

PLCL1

Inactive phospholipase C-like protein 1

Also known as: PLC-L, PLCE, PLCL, PLCL1_HUMAN, PPP1R127, PRIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15111
Gene: PLCL1
Ensembl: ENSG00000115896
Chromosome: 2
Canonical length: 1095 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GABA receptor binding activity and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of cold-induced thermogenesis; and phosphatidylinositol-mediated signaling. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1095 residues, UniProt reviewed canonical sequence.

>Q15111|PLCL1
     1  MAEGAAGRED PAPPDAAGGE DDPRVGPDAA GDCVTAASGG RMRDRRSGVA LPGAAGTPAD
    61  SEAGLLEAAR ATPRRSSIIK DPSNQKCGGR KKTVSFSSMP SEKKISSAND CISFMQAGCE
   121  LKKVRPNSRI YNRFFTLDTD LQALRWEPSK KDLEKAKLDI SAIKEIRLGK NTETFRNNGL
   181  ADQICEDCAF SILHGENYES LDLVANSADV ANIWVSGLRY LVSRSKQPLD FMEGNQNTPR
   241  FMWLKTVFEA ADVDGNGIML EDTSVELIKQ LNPTLKEAKI RLKFKEIQKS KEKLTTRVTE
   301  EEFCEAFCEL CTRPEVYFLL VQISKNKEYL DANDLMLFLE AEQGVTHITE DICLDIIRRY
   361  ELSEEGRQKG FLAIDGFTQY LLSSECDIFD PEQKKVAQDM TQPLSHYYIN ASHNTYLIED
   421  QFRGPADING YIRALKMGCR SVELDVSDGS DNEPILCNRN NMTTHVSFRS VIEVINKFAF
   481  VASEYPLILC LGNHCSLPQQ KVMAQQMKKV FGNKLYTEAP LPSESYLPSP EKLKRMIIVK
   541  GKKLPSDPDV LEGEVTDEDE EAEMSRRMSV DYNGEQKQIR LCRELSDLVS ICKSVQYRDF
   601  ELSMKSQNYW EMCSFSETEA SRIANEYPED FVNYNKKFLS RIYPSAMRID SSNLNPQDFW
   661  NCGCQIVAMN FQTPGPMMDL HTGWFLQNGG CGYVLRPSIM RDEVSYFSAN TKGILPGVSP
   721  LALHIKIISG QNFPKPKGAC AKGDVIDPYV CIEIHGIPAD CSEQRTKTVQ QNSDNPIFDE
   781  TFEFQVNLPE LAMIRFVVLD DDYIGDEFIG QYTIPFECLQ PGYRHVPLRS FVGDIMEHVT
   841  LFVHIAITNR SGGGKAQKRS LSVRMGKKVR EYTMLRNIGL KTIDDIFKIA VHPLREAIDM
   901  RENMQNAIVS IKELCGLPPI ASLKQCLLTL SSRLITSDNT PSVSLVMKDS FPYLEPLGAI
   961  PDVQKKMLTA YDLMIQESRF LIEMADTVQE KIVQCQKAGM EFHEELHNLG AKEGLKGRKL
  1021  NKATESFAWN ITVLKGQGDL LKNAKNEAIE NMKQIQLACL SCGLSKAPSS SAEAKSKRSL
  1081  EAIEEKESSE ENGKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLCL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

tongue: 38 nTPM
heart muscle: 30 nTPM
kidney: 29 nTPM
skeletal muscle: 29 nTPM
spinal cord: 28 nTPM
midbrain: 17 nTPM

Single-cell type

distal convoluted tubule cells: 2,271 nCPM
oligodendrocytes: 2,121 nCPM
endometrial stromal cells: 1,975 nCPM
pituicytes/fscs: 1,901 nCPM
renal collecting duct intercalated cells: 1,874 nCPM
choroid plexus epithelial cells: 1,514 nCPM

Immune cell

T-reg: 1.4 nTPM
MAIT T-cell: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM
naive CD4 T-cell: 0.4 nTPM
neutrophil: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

white matter: 143 nTPM
medulla oblongata: 101 nTPM
basal ganglia: 95 nTPM
midbrain: 90 nTPM
pons: 86 nTPM
cerebellum: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.01
gnomAD missense Z: 1.86
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLCL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLCL1 as an antibody target. Whether an autoantibody or antibody against PLCL1 could matter depends on whether native PLCL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLCL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLCL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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