Seroatlas · Human Serome Atlas

PRKCE

Protein kinase C epsilon type

Also known as: KPCE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02156
Gene
PRKCE
Ensembl
ENSG00000171132
Chromosome
2
Canonical length
737 aa
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Intermediate filaments,Cytosol

OverviewNCBI Gene

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

737 residues, UniProt reviewed canonical sequence.

>Q02156|PRKCE
     1  MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT
    61  NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE
   121  PEGRVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP
   181  TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD QVGSQRFSVN
   241  MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA
   301  KVLADLGVTP DKITNSGQRR KKLIAGAESP QPASGSSPSE EDRSKSAPTS PCDQEIKELE
   361  NNIRKALSFD NRGEEHRAAS SPDGQLMSPG ENGEVRQGQA KRLGLDEFNF IKVLGKGSFG
   421  KVMLAELKGK DEVYAVKVLK KDVILQDDDV DCTMTEKRIL ALARKHPYLT QLYCCFQTKD
   481  RLFFVMEYVN GGDLMFQIQR SRKFDEPRSR FYAAEVTSAL MFLHQHGVIY RDLKLDNILL
   541  DAEGHCKLAD FGMCKEGILN GVTTTTFCGT PDYIAPEILQ ELEYGPSVDW WALGVLMYEM
   601  MAGQPPFEAD NEDDLFESIL HDDVLYPVWL SKEAVSILKA FMTKNPHKRL GCVASQNGED
   661  AIKQHPFFKE IDWVLLEQKK IKPPFKPRIK TKRDVNNFDQ DFTREEPVLT LVDEAIVKQI
   721  NQEEFKGFSY FGEDLMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKCE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 29 nTPM
  • cerebellum: 25 nTPM
  • lung: 19 nTPM
  • hippocampal formation: 18 nTPM
  • retina: 14 nTPM
  • amygdala: 12 nTPM

Single-cell type

  • late spermatids: 932 nCPM
  • corticotrophs: 696 nCPM
  • pancreatic islet cells: 635 nCPM
  • renal collecting duct intercalated cells: 631 nCPM
  • transitional alveolar cells: 584 nCPM
  • early spermatids: 575 nCPM

Immune cell

  • naive B-cell: 1.8 nTPM
  • memory B-cell: 1.5 nTPM
  • myeloid DC: 0.8 nTPM
  • eosinophil: 0.7 nTPM
  • non-classical monocyte: 0.6 nTPM
  • classical monocyte: 0.5 nTPM

Brain region

  • cerebral cortex: 161 nTPM
  • hippocampal formation: 155 nTPM
  • white matter: 123 nTPM
  • basal ganglia: 121 nTPM
  • cerebellum: 97 nTPM
  • pons: 92 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKCE.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 78 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • PRKCE-associated disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
3.77
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKCE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKCE as an antibody target. Whether an autoantibody or antibody against PRKCE could matter depends on whether native PRKCE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKCE is annotated at the cell surface, where native PRKCE is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRKCE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKCE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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