Seroatlas · Human Serome Atlas

SYT10

Synaptotagmin-10

Also known as: SYT10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6XYQ8
Gene
SYT10
Ensembl
ENSG00000110975
Chromosome
12
Canonical length
523 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable several functions, including calcium ion binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in positive regulation of calcium ion-dependent exocytosis; presynaptic dense core vesicle exocytosis; and sensory perception of smell. Predicted to be located in transport vesicle membrane. Predicted to be active in several cellular components, including exocytic vesicle; glutamatergic synapse; and presynapse. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q6XYQ8|SYT10
     1  MSFHKEDGVN SLCQKALHIV TELCFAGQVE WEKCSGIFPR DRGSQGGSST DISVSLLAVV
    61  VSFCGLALLV VSLFVFWKLC WPCWKSKPVT SNITTLPQSI SSAPTEVFET EEKKEIKENE
   121  KPAVKAIEPA IKISHTSPDI PAEVQTALKE HLIKHARVQR QITEPTSSTR HSSFRRHLPR
   181  QMQVSSVDFS MGTEPVLQRG ETTTSIGRIK PELYKQKSVD SEGNQNEDVK ICGKLNFTLQ
   241  YDYENELLVV KIIKALDLPA KDFTGTSDPY VKMYLLPDRK KKFQTRVHRK TLNPLFDETF
   301  QFPVAYDQLS NRKLHFSVYD FDRFSRHDMI GEVILDNLFE VSDLSREATV WKDIHCATTE
   361  SIDLGEIMFS LCYLPTAGRM TLTVIKCRNL KAMDITGSSD PYVKVSLMCE GRRLKKRKTT
   421  TKKNTLNPVY NEAIIFDIPP ENVDQVSLSI AVMDYDRVGH NEVIGVCRTG LDAEGLGRDH
   481  WNEMLAYHRK PITHWHPLLE LPGRATSFDS QGSCPSPKPP STP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
2.1 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 2.1 nTPM
  • colon: 0.7 nTPM
  • kidney: 0.7 nTPM
  • seminal vesicle: 0.7 nTPM
  • cerebral cortex: 0.6 nTPM
  • cervix: 0.5 nTPM

Single-cell type

  • thyrotrophs: 165 nCPM
  • lactotrophs: 151 nCPM
  • ependymal cells: 121 nCPM
  • renal collecting duct intercalated cells: 92 nCPM
  • somatotrophs: 78 nCPM
  • fallopian tube ciliated cells: 66 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 15 nTPM
  • pons: 11 nTPM
  • spinal cord: 6.8 nTPM
  • basal ganglia: 5.8 nTPM
  • midbrain: 5.4 nTPM
  • medulla oblongata: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
0.29
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT10 as an antibody target. Whether an autoantibody or antibody against SYT10 could matter depends on whether native SYT10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYT10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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