Seroatlas · Human Serome Atlas

TC2N

Tandem C2 domains nuclear protein

Also known as: C14orf47, C2CD1, FLJ36557, MTAC2D1, Tac2-N, TAC2N_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9U0
Gene: TC2N
Ensembl: ENSG00000165929
Chromosome: 14
Canonical length: 490 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q8N9U0|TC2N
     1  MATEFIKSCC GGCFYGETEK HNFSVERDFK AAVPNSQNAT ISVPPLTSVS VKPQLGCTED
    61  YLLSKLPSDG KEVPFVVPKF KLSYIQPRTQ ETPSHLEELE GSARASFGDR KVELSSSSQH
   121  GPSYDVYNPF YMYQHISPDL SRRFPPRSEV KRLYGSVCDL RTNKLPGSPG LSKSMFDLTN
   181  SSQRFIQRHD SLSSVPSSSS SRKNSQGSNR SLDTITLSGD ERDFGRLNVK LFYNSSVEQI
   241  WITVLQCRDL SWPSSYGDTP TVSIKGILTL PKPVHFKSSA KEGSNAIEFM ETFVFAIKLQ
   301  NLQTVRLVFK IQTQTPRKKT IGECSMSLRT LSTQEMDYSL DITPPSKISV CHAELELGTC
   361  FQAVNSRIQL QILEARYLPS SSTPLTLSFF VKVGMFSSGE LIYKKKTRLL KASNGRVKWG
   421  ETMIFPLIQS EKEIVFLIKL YSRSSVRRKH FVGQIWISED SNNIEAVNQW KETVINPEKV
   481  VIRWHKLNPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TC2N can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

pancreas: 98 nTPM
blood vessel: 52 nTPM
salivary gland: 44 nTPM
breast: 26 nTPM
gallbladder: 24 nTPM
stomach: 24 nTPM

Single-cell type

t-cells: 233 nCPM
papillary tip epithelial cells: 111 nCPM
renal collecting duct principal cells: 107 nCPM
breast lactating cells: 104 nCPM
nk-cells: 91 nCPM
innate lymphoid cells: 61 nCPM

Immune cell

MAIT T-cell: 85 nTPM
memory CD8 T-cell: 49 nTPM
memory CD4 T-cell: 42 nTPM
NK-cell: 39 nTPM
gdT-cell: 39 nTPM
naive CD4 T-cell: 34 nTPM

Brain region

medulla oblongata: 8.5 nTPM
spinal cord: 4.8 nTPM
choroid plexus: 4.7 nTPM
basal ganglia: 2.9 nTPM
hypothalamus: 2.9 nTPM
pons: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

C2 domain
C2 domain superfamily
C2 domain
Tandem C2 domains nuclear protein
Tandem C2 domains nuclear protein, C2A domain
Tandem C2 domains nuclear protein, C2B domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TC2N as an antibody target. Whether an autoantibody or antibody against TC2N could matter depends on whether native TC2N is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TC2N is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TC2N as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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