Seroatlas · Human Serome Atlas

SYT6

Synaptotagmin-6

Also known as: SYT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T7P8
Gene
SYT6
Ensembl
ENSG00000134207
Chromosome
1
Canonical length
510 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q5T7P8|SYT6
     1  MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS AAGAGTSVSL
    61  LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN PPLEALQSPS FRGNMADKLK
   121  DPSTLGFLEA AVKISHTSPD IPAEVQMSVK EHIMRHTRLQ RQTTEPASST RHTSFKRHLP
   181  RQMHVSSVDY GNELPPAAEQ PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD
   241  YETETLIVRI LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF
   301  PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK DIQYATSESV
   361  DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY VKVSLLCDGR RLKKKKTTIK
   421  KNTLNPVYNE AIIFDIPPEN MDQVSLLISV MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN
   481  EMLAYPRKPI AHWHSLVEVK KSFKEGNPRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
7.4 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 7.4 nTPM
  • basal ganglia: 3.7 nTPM
  • cerebral cortex: 3.3 nTPM
  • pancreas: 2.9 nTPM
  • spinal cord: 1.7 nTPM
  • midbrain: 1.6 nTPM

Single-cell type

  • microglia: 127 nCPM
  • retinal amacrine cells: 81 nCPM
  • other brain neurons: 30 nCPM
  • pancreatic duct cells: 30 nCPM
  • late spermatids: 26 nCPM
  • early spermatids: 21 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 29 nTPM
  • spinal cord: 18 nTPM
  • medulla oblongata: 11 nTPM
  • thalamus: 11 nTPM
  • midbrain: 10 nTPM
  • white matter: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0.01
gnomAD missense Z
0.17
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT6 as an antibody target. Whether an autoantibody or antibody against SYT6 could matter depends on whether native SYT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT6 is annotated at the cell surface, where native SYT6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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