Seroatlas · Human Serome Atlas

UVRAG

UV radiation resistance-associated gene protein

Also known as: UVRAG_HUMAN, VPS38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2Y5
Gene
UVRAG
Ensembl
ENSG00000198382
Chromosome
11
Canonical length
699 aa
Protein class
Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>Q9P2Y5|UVRAG
     1  MSASASVGGP VPQPPPGPAA ALPPGSAARA LHVELPSQQR RLRHLRNIAA RNIVNRNGHQ
    61  LLDTYFTLHL CSTEKIYKEF YRSEVIKNSL NPTWRSLDFG IMPDRLDTSV SCFVVKIWGG
   121  KENIYQLLIE WKVCLDGLKY LGQQIHARNQ NEIIFGLNDG YYGAPFEHKG YSNAQKTILL
   181  QVDQNCVRNS YDVFSLLRLH RAQCAIKQTQ VTVQKIGKEI EEKLRLTSTS NELKKKSECL
   241  QLKILVLQNE LERQKKALGR EVALLHKQQI ALQDKGSAFS AEHLKLQLQK ESLNELRKEC
   301  TAKRELFLKT NAQLTIRCRQ LLSELSYIYP IDLNEHKDYF VCGVKLPNSE DFQAKDDGSI
   361  AVALGYTAHL VSMISFFLQV PLRYPIIHKG SRSTIKDNIN DKLTEKEREF PLYPKGGEKL
   421  QFDYGVYLLN KNIAQLRYQH GLGTPDLRQT LPNLKNFMEH GLMVRCDRHH TSSAIPVPKR
   481  QSSIFGGADV GFSGGIPSPD KGHRKRASSE NERLQYKTPP PSYNSALAQP VTTVPSMGET
   541  ERKITSLSSS LDTSLDFSKE NKKKGEDLVG SLNGGHANVH PSQEQGEALS GHRATVNGTL
   601  LPSEQAGSAS VQLPGEFHPV SEAELCCTVE QAEEIIGLEA TGFASGDQLE AFNCIPVDSA
   661  VAVECDEQVL GEFEEFSRRI YALNENVSSF RRPRRSSDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UVRAG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 32 nTPM
  • adipose tissue: 31 nTPM
  • choroid plexus: 25 nTPM
  • lymph node: 25 nTPM
  • tonsil: 24 nTPM
  • thymus: 24 nTPM

Single-cell type

  • choroid plexus epithelial cells: 871 nCPM
  • cdc: 823 nCPM
  • b-cells: 673 nCPM
  • microglia: 612 nCPM
  • adipocytes: 570 nCPM
  • pdcs: 491 nCPM

Immune cell

  • naive B-cell: 27 nTPM
  • plasmacytoid DC: 24 nTPM
  • memory B-cell: 23 nTPM
  • myeloid DC: 17 nTPM
  • neutrophil: 14 nTPM
  • non-classical monocyte: 12 nTPM

Brain region

  • choroid plexus: 93 nTPM
  • white matter: 67 nTPM
  • basal ganglia: 52 nTPM
  • pons: 52 nTPM
  • spinal cord: 51 nTPM
  • midbrain: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
1.49
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UVRAG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UVRAG as an antibody target. Whether an autoantibody or antibody against UVRAG could matter depends on whether native UVRAG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UVRAG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UVRAG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UVRAG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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