Seroatlas · Human Serome Atlas

SYT4

Synaptotagmin-4

Also known as: HsT1192, KIAA1342, SYT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H2B2
Gene
SYT4
Ensembl
ENSG00000132872
Chromosome
18
Canonical length
425 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable several functions, including calcium ion sensor activity; protein dimerization activity; and syntaxin binding activity. Involved in negative regulation of catecholamine secretion and positive regulation of dendrite extension. Predicted to be located in neuron projection terminus and secretory vesicle. Predicted to be active in several cellular components, including axon; glutamatergic synapse; and secretory vesicle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q9H2B2|SYT4
     1  MAPITTSREE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR KSSKSNKTPP YKFVHVLKGV
    61  DIYPENLNSK KKFGADDKNE VKNKPAVPKN SLHLDLEKRD LNGNFPKTNL KPGSPSDLEN
   121  ATPKLFLEGE KESVSPESLK SSTSLTSEEK QEKLGTLFFS LEYNFERKAF VVNIKEARGL
   181  PAMDEQSMTS DPYIKMTILP EKKHKVKTRV LRKTLDPAFD ETFTFYGIPY TQIQELALHF
   241  TILSFDRFSR DDIIGEVLIP LSGIELSEGK MLMNREIIKR NVRKSSGRGE LLISLCYQST
   301  TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP NAVFNELFVF
   361  DIPCEGLEDI SVEFLVLDSE RGSRNEVIGQ LVLGAAAEGT GGEHWKEICD YPRRQIAKWH
   421  VLCDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
141 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 141 nTPM
  • cerebral cortex: 49 nTPM
  • hypothalamus: 45 nTPM
  • pituitary gland: 30 nTPM
  • basal ganglia: 25 nTPM
  • retina: 23 nTPM

Single-cell type

  • pancreatic islet cells: 133 nCPM
  • brain excitatory neurons: 122 nCPM
  • corticotrophs: 117 nCPM
  • somatotrophs: 109 nCPM
  • other brain neurons: 99 nCPM
  • lactotrophs: 81 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 195 nTPM
  • hypothalamus: 152 nTPM
  • cerebral cortex: 132 nTPM
  • pons: 124 nTPM
  • basal ganglia: 84 nTPM
  • midbrain: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.44
gnomAD missense Z
0.06
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT4 as an antibody target. Whether an autoantibody or antibody against SYT4 could matter depends on whether native SYT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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