Seroatlas · Human Serome Atlas

SYT11

Synaptotagmin-11

Also known as: DKFZp781D015, KIAA0080, MGC10881, MGC17226, SYT11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BT88
Gene
SYT11
Ensembl
ENSG00000132718
Chromosome
1
Canonical length
431 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q9BT88|SYT11
     1  MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN PPYKFIHMLK
    61  GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE AGLLSRDKDP RGPSSGSCID
   121  QLPIKMDYGE ELRSPITSLT PGESKTTSPS SPEEDVMLGS LTFSVDYNFP KKALVVTIQE
   181  AHGLPVMDDQ TQGSDPYIKM TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL
   241  VLHFLVLSFD RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS
   301  YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV KKCTLNPIFN
   361  ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA HSVTASGAEH WREVCESPRK
   421  PVAKWHSLSE Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
228 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 228 nTPM
  • basal ganglia: 132 nTPM
  • spinal cord: 121 nTPM
  • cerebellum: 104 nTPM
  • midbrain: 101 nTPM
  • amygdala: 100 nTPM

Single-cell type

  • oligodendrocytes: 215 nCPM
  • oligodendrocyte progenitor cells: 196 nCPM
  • müller glia: 193 nCPM
  • pituicytes/fscs: 176 nCPM
  • astrocytes: 149 nCPM
  • brain inhibitory neurons: 134 nCPM

Immune cell

  • T-reg: 17 nTPM
  • gdT-cell: 17 nTPM
  • memory CD8 T-cell: 12 nTPM
  • naive CD8 T-cell: 8.9 nTPM
  • memory CD4 T-cell: 8.8 nTPM
  • non-classical monocyte: 8.5 nTPM

Brain region

  • white matter: 379 nTPM
  • thalamus: 334 nTPM
  • spinal cord: 312 nTPM
  • cerebellum: 311 nTPM
  • basal ganglia: 304 nTPM
  • midbrain: 303 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.93
gnomAD missense Z
1.68
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT11 as an antibody target. Whether an autoantibody or antibody against SYT11 could matter depends on whether native SYT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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