PLCL2

Protein identityUniProt · HPA

UniProt accession

Q9UPR0

Gene

PLCL2

Ensembl

ENSG00000154822

Chromosome

3

Canonical length

1127 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Enables GABA receptor binding activity. Predicted to be involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of cold-induced thermogenesis; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within B cell proliferation involved in immune response; B-1a B cell differentiation; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1127 residues, UniProt reviewed canonical sequence.

>Q9UPR0|PLCL2
     1  MAECGRGGAA GGALPTSPGP ALGAKGALKA GVGEGGGGGG RLGHGRARYD SGGVSNGDCS
    61  LGVSGDEARA SPTRGPRGVA LAPTPSAVVC TLPRESKPGG LPRRSSIIKD GTKQKRERKK
   121  TVSFSSMPTE KKISSASDCI NSMVEGSELK KVRSNSRIYH RYFLLDADMQ SLRWEPSKKD
   181  SEKAKIDIKS IKEVRTGKNT DIFRSNGISD QISEDCAFSV IYGENYESLD LVANSADVAN
   241  IWVTGLRYLI SYGKHTLDML ESSQDNMRTS WVSQMFSEID VDNLGHITLC NAVQCIRNLN
   301  PGLKTSKIEL KFKELHKSKD KAGTEVTKEE FIEVFHELCT RPEIYFLLVQ FSSNKEFLDT
   361  KDLMMFLEAE QGVAHINEEI SLEIIHKYEP SKEGQEKGWL SIDGFTNYLM SPDCYIFDPE
   421  HKKVCQDMKQ PLSHYFINSS HNTYLIEDQF RGPSDITGYI RALKMGCRSV ELDVWDGPDN
   481  EPVIYTGHTM TSQIVFRSVI DIINKYAFFA SEYPLILCLE NHCSIKQQKV MVQHMKKLLG
   541  DKLYTTSPNV EESYLPSPDV LKGKILIKAK KLSSNCSGVE GDVTDEDEGA EMSQRMGKEN
   601  MEQPNNVPVK RFQLCKELSE LVSICKSVQF KEFQVSFQVQ KYWEVCSFNE VLASKYANEN
   661  PGDFVNYNKR FLARVFPSPM RIDSSNMNPQ DFWKCGCQIV AMNFQTPGLM MDLNIGWFRQ
   721  NGNCGYVLRP AIMREEVSFF SANTKDSVPG VSPQLLHIKI ISGQNFPKPK GSGAKGDVVD
   781  PYVYVEIHGI PADCAEQRTK TVHQNGDAPI FDESFEFQIN LPELAMVRFV VLDDDYIGDE
   841  FIGQYTIPFE CLQTGYRHVP LQSLTGEVLA HASLFVHVAI TNRRGGGKPH KRGLSVRKGK
   901  KSREYASLRT LWIKTVDEVF KNAQPPIRDA TDLRENMQNA VVSFKELCGL SSVANLMQCM
   961  LAVSPRFLGP DNTPLVVLNL SEQYPTMELQ GIVPEVLKKI VTTYDMMIQS LKALIENADA
  1021  VYEKIVHCQK AAMEFHEHLH SIGTKEGLKE RKLQKAVESF TWNITILKGQ ADLLKYAKNE
  1081  TLENLKQIHF AAVSCGLNKP GTENADVQKP RRSLEVIPEK ANDETGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.09

gnomAD pLI

1

gnomAD missense Z

3.33

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• B cell proliferation involved in immune response
• B-1a B cell differentiation
• gamma-aminobutyric acid signaling pathway
• negative regulation of B cell receptor signaling pathway
• negative regulation of cold-induced thermogenesis
• phosphatidylinositol metabolic process
• phosphatidylinositol-mediated signaling
• regulation of synaptic transmission, GABAergic
• release of sequestered calcium ion into cytosol

Molecular functions

• GABA receptor binding
• inositol 1,4,5 trisphosphate binding
• phosphatidylinositol-4,5-bisphosphate phospholipase C activity

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• C2 domain
• Phosphatidylinositol-specific phospholipase C, X domain
• Phosphoinositide phospholipase C family
• Phospholipase C, phosphatidylinositol-specific, Y domain
• Pleckstrin homology domain
• EF-hand domain pair
• PH-like domain superfamily
• Phosphoinositide-specific phospholipase C, EF-hand-like domain
• PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
• C2 domain superfamily
• C2 domain
• Phosphatidylinositol-specific phospholipase C, Y domain
• Phosphatidylinositol-specific phospholipase C, X domain
• Phosphoinositide-specific phospholipase C, efhand-like
• Pleckstrin homology domain
• Inactive phospholipase C-like protein 2, EF-hand domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Phosphoprotein
• Transducer

InteractionsUniProt · HPA

Protein binding partners of PLCL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PPP1CA