C-type lectin fold
IPR016187
Definition
Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity PMID:14533786, they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions PMID:12223269. There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins PMID:15476922. This entry represents a structural domain found in C-type lectins, as well as in other proteins, including: The N-terminal domain of aerolysin PMID:7510043 and the N-terminal domain of the S2/S3 subunit of pertussis toxin PMID:8637000. The C-terminal domain of invasin PMID:10514372 and intimin PMID:10890451. Link domain, which includes the Link module of TSG-6 PMID:12972412 (a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal β-strand and C-terminal β-hairpin) PMID:14992719. Endostatin PMID:9724722 and the endostatin domain of collagen alpha 1 (XV) PMID:966814, these domains being decorated with many insertions in the common fold. The noncollagenous (NC1) domain of collagen IV, which consists of a duplication of the C-type lectin domain, with segment swapping within and between individual domains PMID:12011424. Sulphatase-modifying factors (C-alpha-formyglycine-generating enzyme), where the fold is decorated with many additional structures [[cite:PMID:16041070], [cite:PMID:15687489]]. The C-terminal domain of the major tropism determinant (Mtd), where the fold is decorated with many additional structures, and has an overall similarity to the sulphatase modifying factor family but lacking the characteristic disulphide PMID:16170324.
108 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (108 proteins: gene, accession, name)
- ACAN
- ASGR1
- ASGR2
- ATRN
- ATRNL1
- BCAN
- CD207
- CD209
- CD248
- CD302
- CD44
- CD69
- CD72
- CD93
- CHODL
- CLEC10A
- CLEC11A
- CLEC12A
- CLEC12B
- CLEC14A
- CLEC17A
- CLEC18A
- CLEC18B
- CLEC18C
- CLEC19A
- CLEC1A
- CLEC1B
- CLEC20A
- CLEC2A
- CLEC2B
- CLEC2D
- CLEC2L
- CLEC3A
- CLEC3B
- CLEC4A
- CLEC4C
- CLEC4D
- CLEC4E
- CLEC4F
- CLEC4G
- CLEC4M
- CLEC5A
- CLEC6A
- CLEC7A
- CLEC9A
- CLECL1P
- COL15A1
- COL18A1
- COL4A1
- COL4A2
- COL4A3
- COL4A4
- COL4A5
- COL4A6
- COLEC10
- COLEC11
- COLEC12
- DGCR2
- FCER2
- FREM1
- HAPLN1
- HAPLN2
- HAPLN3
- HAPLN4
- KLRB1
- KLRC1
- KLRC2
- KLRC3
- KLRC4
- KLRD1
- KLRF1
- KLRF2
- KLRG1
- KLRG2
- KLRK1
- LAYN
- LY75
- LYVE1
- MBL2
- MRC1
- MRC2
- NCAN
- OLR1
- PKD1
- PKD1L2
- PKD1L3
- PLA2R1
- PRG2
- PRG3
- REG1A
- REG1B
- REG3A
- REG3G
- REG4
- SELE
- SELL
- SELP
- SFTPA1
- SFTPA2
- SFTPD
- STAB1
- STAB2
- SUMF1
- SUMF2
- SUSD5
- THBD
- TNFAIP6
- VCAN
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