Seroatlas · Human Serome Atlas

COLEC10

Collectin-10

Also known as: CL-10, CL-L1, COL10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6Z7
Gene
COLEC10
Ensembl
ENSG00000184374
Chromosome
8
Canonical length
277 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>Q9Y6Z7|COLEC10
     1  MNGFASLLRR NQFILLVLFL LQIQSLGLDI DSRPTAEVCA THTISPGPKG DDGEKGDPGE
    61  EGKHGKVGRM GPKGIKGELG DMGDQGNIGK TGPIGKKGDK GEKGLLGIPG EKGKAGTVCD
   121  CGRYRKFVGQ LDISIARLKT SMKFVKNVIA GIRETEEKFY YIVQEEKNYR ESLTHCRIRG
   181  GMLAMPKDEA ANTLIADYVA KSGFFRVFIG VNDLEREGQY MFTDNTPLQN YSNWNEGEPS
   241  DPYGHEDCVE MLSSGRWNDT ECHLTMYFVC EFIKKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COLEC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • liver: 61 nTPM
  • placenta: 10 nTPM
  • thyroid gland: 1.9 nTPM
  • lung: 1 nTPM
  • gallbladder: 0.6 nTPM
  • heart muscle: 0.4 nTPM

Single-cell type

  • hepatic stellate cells: 84 nCPM
  • loop of henle epithelial cells: 78 nCPM
  • oocytes: 51 nCPM
  • renal connecting tubule cells: 30 nCPM
  • papillary tip epithelial cells: 23 nCPM
  • renal collecting duct principal cells: 21 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 1 nTPM
  • choroid plexus: 0.5 nTPM
  • medulla oblongata: 0.5 nTPM
  • pons: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • spinal cord: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COLEC10.

Disease | AllUniProt

Conditions COLEC10 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 63 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • 3MC syndrome 3
  • See cases
  • COLEC10-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COLEC10 as an antibody target. Whether an autoantibody or antibody against COLEC10 could matter depends on whether native COLEC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COLEC10 is annotated as secreted, so native COLEC10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label COLEC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COLEC10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...