Seroatlas · Human Serome Atlas

CLEC19A

C-type lectin domain family 19 member A

Also known as: CL19A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXS0
Gene: CLEC19A
Ensembl: ENSG00000261210
Chromosome: 16
Canonical length: 186 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>Q6UXS0|CLEC19A
     1  MQRWTLWAAA FLTLHSAQAF PQTDISISPA LPELPLPSLC PLFWMEFKGH CYRFFPLNKT
    61  WAEADLYCSE FSVGRKSAKL ASIHSWEENV FVYDLVNSCV PGIPADVWTG LHDHRQEGQF
   121  EWTDGSSYDY SYWDGSQPDD GVHADPEEED CVQIWYRPTS ALRSWNDNTC SRKFPFVCKI
   181  PSLTIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC19A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 1.3 nTPM
choroid plexus: 0.4 nTPM
skin: 0.3 nTPM
prostate: 0.2 nTPM
retina: 0.2 nTPM
epididymis: 0.1 nTPM

Single-cell type

respiratory ciliated cells: 81 nCPM
microglia: 29 nCPM
fallopian tube ciliated cells: 22 nCPM
endometrial ciliated cells: 16 nCPM
respiratory deuterosomal cells: 10 nCPM
foveolar cells: 9.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 7.9 nTPM
amygdala: 7.5 nTPM
hippocampal formation: 6 nTPM
cerebellum: 4.9 nTPM
basal ganglia: 4.2 nTPM
midbrain: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.81

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carbohydrate binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

C-type lectin-like
C-type lectin-like/link domain superfamily
C-type lectin fold
C-type lectin, conserved site
C-type lectin and snaclec domain-containing protein
Lectin C-type domain
CEL-1-like C-type lectin-like domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC19A as an antibody target. Whether an autoantibody or antibody against CLEC19A could matter depends on whether native CLEC19A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC19A is annotated as secreted, so native CLEC19A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLEC19A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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