SELP

Protein identityUniProt · HPA

UniProt accession

P16109

Gene

SELP

Ensembl

ENSG00000174175

Chromosome

1

Canonical length

830 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

830 residues, UniProt reviewed canonical sequence.

>P16109|SELP
     1  MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA YSWNISRKYC
    61  QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT WTWVGTKKAL TNEAENWADN
   121  EPNNKRNNED CVEIYIKSPS APGKWNDEHC LKKKHALCYT ASCQDMSCSK QGECLETIGN
   181  YTCSCYPGFY GPECEYVREC GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS
   241  KLECLASGIW TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG
   301  PEVVQCTASG VWTAPAPVCK AVQCQHLEAP SEGTMDCVHP LTAFAYGSSC KFECQPGYRV
   361  RGLDMLRCID SGHWSAPLPT CEAISCEPLE SPVHGSMDCS PSLRAFQYDT NCSFRCAEGF
   421  MLRGADIVRC DNLGQWTAPA PVCQALQCQD LPVPNEARVN CSHPFGAFRY QSVCSFTCNE
   481  GLLLVGASVL QCLATGNWNS VPPECQAIPC TPLLSPQNGT MTCVQPLGSS SYKSTCQFIC
   541  DEGYSLSGPE RLDCTRSGRW TDSPPMCEAI KCPELFAPEQ GSLDCSDTRG EFNVGSTCHF
   601  SCDNGFKLEG PNNVECTTSG RWSATPPTCK GIASLPTPGV QCPALTTPGQ GTMYCRHHPG
   661  TFGFNTTCYF GCNAGFTLIG DSTLSCRPSG QWTAVTPACR AVKCSELHVN KPIAMNCSNL
   721  WGNFSYGSIC SFHCLEGQLL NGSAQTACQE NGHWSTTVPT CQAGPLTIQE ALTYFGGAVA
   781  STIGLIMGGT LLALLRKRFR QKDDGKCPLN PHSHLGTYGV FTNAAFDPSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

13 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SELP.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 137 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Premature coronary artery atherosclerosis

Disease | AutoantibodyPubMed

Conditions in which antibodies against SELP are reported. Each links to that disease's full target list.

• Purpura, Thrombocytopenic, Idiopathic 5
• Thrombocytopenia 4

ReferencesPubMed · IEDB

Publications for SELP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.32

gnomAD pLI

0

gnomAD missense Z

-0.26

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
• cell adhesion
• cell-cell adhesion
• defense response to Gram-negative bacterium
• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
• inflammatory response
• leukocyte cell-cell adhesion
• leukocyte tethering or rolling
• positive regulation of leukocyte migration
• positive regulation of leukocyte tethering or rolling
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of platelet activation
• regulation of integrin activation
• response to cytokine
• response to lipopolysaccharide

Molecular functions

• calcium ion binding
• calcium-dependent protein binding
• fucose binding
• glycosphingolipid binding
• heparin binding
• integrin binding
• lipopolysaccharide binding
• oligosaccharide binding
• sialic acid binding

Cellular components

• external side of plasma membrane
• extracellular space
• plasma membrane
• platelet alpha granule membrane
• platelet dense granule membrane

Protein domainsUniProt · Pfam · InterPro

• Sushi/SCR/CCP domain
• EGF-like domain
• C-type lectin-like
• Selectin superfamily
• C-type lectin-like/link domain superfamily
• C-type lectin fold
• C-type lectin, conserved site
• Selectin, C-type lectin-like domain
• Sushi/SCR/CCP superfamily
• Complement & Cell Adhesion Regulators
• Lectin C-type domain
• Sushi repeat (SCR repeat)

KeywordsUniProt

• Calcium
• Cell adhesion
• Cell membrane
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Lectin
• Lipoprotein
• Membrane
• Metal-binding
• Palmitate
• Repeat
• Signal
• Sushi
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SELP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PODXL2
• SNX17
• ITGA5
• ITGAV
• ITGB1
• ITGA4
• ITGA2B