Seroatlas · Human Serome Atlas

ASGR1

Asialoglycoprotein receptor 1

Also known as: ASGR1_HUMAN, CLEC4H1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07306
Gene
ASGR1
Ensembl
ENSG00000141505
Chromosome
17
Canonical length
291 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Vesicles,Cell Junctions
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>P07306|ASGR1
     1  MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL LLLVVVCVIG
    61  SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR KMKSLESQLE KQQKDLSEDH
   121  SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE RTCCPVNWVE HERSCYWFSR SGKAWADADN
   181  YCRLEDAHLV VVTSWEEQKF VQHHIGPVNT WMGLHDQNGP WKWVDGTDYE TGFKNWRPEQ
   241  PDDWYGHGLG GGEDCAHFTD DGRWNDDVCQ RPYRWVCETE LDKASQEPPL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASGR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
1,142 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,142 nTPM
  • testis: 25 nTPM
  • cerebellum: 22 nTPM
  • cerebral cortex: 14 nTPM
  • hypothalamus: 6.9 nTPM
  • amygdala: 6.7 nTPM

Single-cell type

  • hepatocytes: 1,287 nCPM
  • early spermatids: 317 nCPM
  • late spermatids: 142 nCPM
  • monocytes: 94 nCPM
  • cholangiocytes: 56 nCPM
  • late primary spermatocytes: 52 nCPM

Immune cell

  • classical monocyte: 115 nTPM
  • intermediate monocyte: 56 nTPM
  • myeloid DC: 41 nTPM
  • total PBMC: 37 nTPM
  • non-classical monocyte: 15 nTPM
  • basophil: 10 nTPM

Brain region

  • cerebellum: 32 nTPM
  • cerebral cortex: 20 nTPM
  • pons: 15 nTPM
  • white matter: 15 nTPM
  • midbrain: 15 nTPM
  • thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASGR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASGR1 as an antibody target. Whether an autoantibody or antibody against ASGR1 could matter depends on whether native ASGR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASGR1 is annotated at the cell surface, where native ASGR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ASGR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASGR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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