Seroatlas · Human Serome Atlas

CLEC2L

C-type lectin domain family 2 member L

Also known as: CLC2L_HUMAN, FLJ32986

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7M8
Gene: CLEC2L
Ensembl: ENSG00000236279
Chromosome: 7
Canonical length: 214 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>P0C7M8|CLEC2L
     1  MEPAREPPSR ARPPPPLAAR PAPAPAAPRP RSPAEAEARG PEGLLRRSGS GYEGSTSWKA
    61  ALEDTTTRLL LGAIAVLLFA ILVVMSILAS KGCIKCEAPC PEDWLLYGRK CYFFSEEPRD
   121  WNTGRQYCHT HEAVLAVIQS QKELEFMFKF TRREPWIGLR RVGDEFHWVN GDPFDPDTFT
   181  IAGPGECVFV EPTRLVSTEC LMTRPWVCSK MAYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 38 nTPM
cerebellum: 20 nTPM
hippocampal formation: 20 nTPM
midbrain: 18 nTPM
amygdala: 14 nTPM
parathyroid gland: 13 nTPM

Single-cell type

retinal ganglion cells: 147 nCPM
platelets: 65 nCPM
other brain neurons: 55 nCPM
brain inhibitory neurons: 55 nCPM
brain excitatory neurons: 47 nCPM
retinal amacrine cells: 35 nCPM

Immune cell

total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 73 nTPM
cerebral cortex: 71 nTPM
thalamus: 63 nTPM
cerebellum: 56 nTPM
medulla oblongata: 53 nTPM
white matter: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0.01
gnomAD missense Z: 0.53
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carbohydrate binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC2L as an antibody target. Whether an autoantibody or antibody against CLEC2L could matter depends on whether native CLEC2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLEC2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...