Seroatlas · Human Serome Atlas

CLEC12A

C-type lectin domain family 12 member A

Also known as: CD371, CL12A_HUMAN, CLL-1, DCAL-2, MICL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5QGZ9
Gene
CLEC12A
Ensembl
ENSG00000172322
Chromosome
12
Canonical length
265 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q5QGZ9|CLEC12A
     1  MSEEVTYADL QFQNSSEMEK IPEIGKFGEK APPAPSHVWR PAALFLTLLC LLLLIGLGVL
    61  ASMFHVTLKI EMKKMNKLQN ISEELQRNIS LQLMSNMNIS NKIRNLSTTL QTIATKLCRE
   121  LYSKEQEHKC KPCPRRWIWH KDSCYFLSDD VQTWQESKMA CAAQNASLLK INNKNALEFI
   181  KSQSRSYDYW LGLSPEEDST RGMRVDNIIN SSAWVIRNAP DLNNMYCGYI NRLYVQYYHC
   241  TYKKRMICEK MANPVQLGST YFREA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC12A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 75 nTPM
  • spleen: 21 nTPM
  • lung: 16 nTPM
  • appendix: 13 nTPM
  • smooth muscle: 7.2 nTPM
  • lymph node: 6.1 nTPM

Single-cell type

  • neutrophil progenitors: 806 nCPM
  • neutrophils: 461 nCPM
  • monocytes: 234 nCPM
  • kupffer cells: 182 nCPM
  • monocyte progenitors: 160 nCPM
  • cdc: 82 nCPM

Immune cell

  • eosinophil: 203 nTPM
  • classical monocyte: 137 nTPM
  • non-classical monocyte: 131 nTPM
  • intermediate monocyte: 115 nTPM
  • myeloid DC: 73 nTPM
  • total PBMC: 62 nTPM

Brain region

  • choroid plexus: 4.2 nTPM
  • medulla oblongata: 2.8 nTPM
  • cerebral cortex: 2.3 nTPM
  • pons: 2.2 nTPM
  • amygdala: 2.1 nTPM
  • basal ganglia: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
-0.22
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC12A as an antibody target. Whether an autoantibody or antibody against CLEC12A could matter depends on whether native CLEC12A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC12A is annotated at the cell surface, where native CLEC12A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC12A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC12A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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