Seroatlas · Human Serome Atlas

CLEC7A

C-type lectin domain family 7 member A

Also known as: CD369, CLC7A_HUMAN, CLECSF12, DECTIN-1, hDectin-1, SCARE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXN2
Gene
CLEC7A
Ensembl
ENSG00000172243
Chromosome
12
Canonical length
247 aa
Protein class
CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q9BXN2|CLEC7A
     1  MEYHPDLENL DEDGYTQLHF DSQSNTRIAV VSEKGSCAAS PPWRLIAVIL GILCLVILVI
    61  AVVLGTMAIW RSNSGSNTLE NGYFLSRNKE NHSQPTQSSL EDSVTPTKAV KTTGVLSSPC
   121  PPNWIIYEKS CYLFSMSLNS WDGSKRQCWQ LGSNLLKIDS SNELGFIVKQ VSSQPDNSFW
   181  IGLSRPQTEV PWLWEDGSTF SSNLFQIRTT ATQENPSPNC VWIHVSVIYD QLCSVPSYSI
   241  CEKKFSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 79 nTPM
  • appendix: 42 nTPM
  • spleen: 32 nTPM
  • lung: 28 nTPM
  • lymph node: 13 nTPM
  • tonsil: 11 nTPM

Single-cell type

  • neutrophils: 664 nCPM
  • kupffer cells: 638 nCPM
  • monocytes: 474 nCPM
  • cdc: 387 nCPM
  • macrophages: 305 nCPM
  • microglia: 221 nCPM

Immune cell

  • neutrophil: 252 nTPM
  • non-classical monocyte: 149 nTPM
  • intermediate monocyte: 137 nTPM
  • classical monocyte: 123 nTPM
  • myeloid DC: 61 nTPM
  • total PBMC: 40 nTPM

Brain region

  • white matter: 16 nTPM
  • medulla oblongata: 13 nTPM
  • thalamus: 11 nTPM
  • spinal cord: 11 nTPM
  • pons: 10 nTPM
  • hypothalamus: 9.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLEC7A.

Disease | AllUniProt

Conditions CLEC7A is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
0.22
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLEC7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC7A as an antibody target. Whether an autoantibody or antibody against CLEC7A could matter depends on whether native CLEC7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC7A is annotated at the cell surface, where native CLEC7A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC7A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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