Seroatlas · Human Serome Atlas

CLEC17A

C-type lectin domain family 17, member A

Also known as: CL17A_HUMAN, FLJ45910

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZS10
Gene: CLEC17A
Ensembl: ENSG00000187912
Chromosome: 19
Canonical length: 378 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables D-mannose binding activity; fucose binding activity; and identical protein binding activity. Predicted to be involved in immune response. Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q6ZS10|CLEC17A
     1  MHNLYSITGY PDPPGTMEEE EEDDDYENST PPYKDLPPKP GTMEEEEEDD DYENSTPPYK
    61  DLPPKPGTME EEEEDDDYEN STPPYKDLPP KPGSSAPPRP PRAAKETEKP PLPCKPRNMT
   121  GLDLAAVTCP PPQLAVNLEP SPLQPSLAAT PVPWLNQRSG GPGCCQKRWM VYLCLLVVTS
   181  LFLGCLGLTV TLIKYQELME ELRMLSFQQM TWRTNMTGMA GLAGLKHDIA RVRADTNQSL
   241  VELWGLLDCR RITCPEGWLP FEGKCYYFSP STKSWDEARM FCQENYSHLV IINSFAEHNF
   301  VAKAHGSPRV YWLGLNDRAQ EGDWRWLDGS PVTLSFWEPE EPNNIHDEDC ATMNKGGTWN
   361  DLSCYKTTYW ICERKCSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC17A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

tonsil: 17 nTPM
lymph node: 15 nTPM
spleen: 10 nTPM
appendix: 7.7 nTPM
small intestine: 5.3 nTPM
bone marrow: 1.9 nTPM

Single-cell type

tuft cells: 69 nCPM
b-cells: 67 nCPM
microglia: 35 nCPM
neutrophils: 20 nCPM
early spermatids: 12 nCPM
cdc: 9.2 nCPM

Immune cell

naive B-cell: 43 nTPM
memory B-cell: 22 nTPM
myeloid DC: 3 nTPM
neutrophil: 2.6 nTPM
total PBMC: 2.2 nTPM
classical monocyte: 0.7 nTPM

Brain region

white matter: 6.8 nTPM
cerebellum: 6.6 nTPM
medulla oblongata: 6.6 nTPM
cerebral cortex: 6.2 nTPM
pons: 6.1 nTPM
hypothalamus: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

immune response

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC17A as an antibody target. Whether an autoantibody or antibody against CLEC17A could matter depends on whether native CLEC17A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC17A is annotated at the cell surface, where native CLEC17A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC17A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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