Seroatlas · Human Serome Atlas

KLRF2

Killer cell lectin-like receptor subfamily F member 2

Also known as: KLRF2_HUMAN, NKp65

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: D3W0D1
Gene: KLRF2
Ensembl: ENSG00000256797
Chromosome: 12
Canonical length: 207 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein homodimerization activity. Predicted to be involved in natural killer cell degranulation and positive regulation of cytokine production. Predicted to act upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>D3W0D1|KLRF2
     1  MENEDGYMTL SFKNRCKSKQ KSKDFSLYPQ YYCLLLIFGC IVILIFIMTG IDLKFWHKKM
    61  DFSQNVNVSS LSGHNYLCPN DWLLNEGKCY WFSTSFKTWK ESQRDCTQLQ AHLLVIQNLD
   121  ELEFIQNSLK PGHFGWIGLY VTFQGNLWMW IDEHFLVPEL FSVIGPTDDR SCAVITGNWV
   181  YSEDCSSTFK GICQRDAILT HNGTSGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

skin: 11 nTPM
tonsil: 0.8 nTPM
duodenum: 0.6 nTPM
lymph node: 0.5 nTPM
thymus: 0.4 nTPM
gallbladder: 0.2 nTPM

Single-cell type

nk-cells: 14 nCPM
innate lymphoid cells: 9.8 nCPM
pdcs: 4.6 nCPM
thymocytes: 4.2 nCPM
suprabasal keratinocytes: 2.7 nCPM
basal keratinocytes: 2.2 nCPM

Immune cell

plasmacytoid DC: 3.2 nTPM
NK-cell: 3.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.09
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLRF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CLEC2A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRF2 as an antibody target. Whether an autoantibody or antibody against KLRF2 could matter depends on whether native KLRF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRF2 is annotated at the cell surface, where native KLRF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KLRF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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