Seroatlas · Human Serome Atlas

PKD1L3

Polycystin-1-like protein 3

Also known as: PK1L3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z443
Gene
PKD1L3
Ensembl
ENSG00000277481
Chromosome
16
Canonical length
1732 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

1732 residues, UniProt reviewed canonical sequence.

>Q7Z443|PKD1L3
     1  MFFKGGSWLW LYIRTSIILG SELNSPAPHG QNNCYQLNRF QCSFEEAQHY CHVQRGFLAH
    61  IWNKEVQDLI RDYLEEGKKW WIGQNVMPLK KHQDNKYPAD VAANGPPKPL SCTYLSRNFI
   121  RISSKGDKCL LKYYFICQTG DFLDGDAHYE RNGNNSHLYQ RHKKTKRGVA IARDKMPPGP
   181  GHLPTTCHYP LPAHLSKTLC HPISQFPSVL SSITSQVTSA ASEPSSQPLP VITQLTMPVS
   241  VTHAGQSLAE TTSSPKEEGH PNTFTSYLQV SLQKASGQVI DEIAGNFSRA VHGLQALNKL
   301  QEACEFLQKL TALTPRFSKP AQVNLINSLI YLSEELLRIP FQNNNSLGFK VPPTVCPFHS
   361  LNNVTKAGEG SWLESKRHTE PVEDILEMSL VEFGNIGEAF LEQNQSPESS VTLTSANATL
   421  LLSRQNISTL PLSSYTLGHP APVRLGFPSA LALKELLNKH PGVNVQITGL AFNPFKDLDN
   481  RNIVGSIGSV LLSANRKLLQ VHDLMEDIEI MLWRNVSLET HPTSLNMSTH QLTITVNVTS
   541  LEKSLIVSID PDSPLLMTLY LGFQYQPNCT HFHLNITLPK DKVWQKDEEY TWVLNPEHLQ
   601  HGIGTYYITA VLSERQEGAQ QTPSLVSVIT AVTQCYYWEI HNQTWSSAGC QVGPQSTILR
   661  TQCLCNHLTF FASDFFVVPR TVNVEDTIKL FLRVTNNPVG VSLLASLLGF YVITVVWARK
   721  KDQADMQKVK VTVLADNDPS AQFHYLIQVY TGYRRSAATT AKVVITLYGS EGRSEPHHLC
   781  DPQKTVFERG GLDVFLLTTW TSLGNLHSLR LWHDNSGVSP SWYVSQVIVC DMAVKRKWHF
   841  LCNCWLAVDL GDCELDRVFI PVSKRELFSF RHLFSSMIVE KFTQDYLWLS IATRHPWNQF
   901  TRVQRLSCCM TLLLCNMVIN VMFWKINSTT AKRDEQMRPF AVAWSELLVS IHTAVILFPI
   961  NLVIGRLFPL IEPQETLPLF PPIQASCLSD ASVEPLSATM VVEELKETVR FLLRRNTYLL
  1021  SKCEQPPWSS WDITKLVKLL SSLVSSHLEG QGCHQQGERH WARVVPENHH HFCCYLHRVL
  1081  QRLKSHLGTL GLTQGHQSCD FLDAASQLQK LQELLETHIL PTEQEPSREV TSFAILSSEE
  1141  GKKPISNGLS KWLTSVCWLL LGFTSLASAF FTALYSLELS KDQATSWMIS IILSVLQNIF
  1201  ISQPVKVVFF TFLYSLMMSR MPRLNKENEQ QTKRILALLA KCSSSVPGSR DKNNPVYVAP
  1261  AINSPTKHPE RTLKKKKLFK LTGDILVQIL FLTLLMTAIY SAKNSNRFYL HQAIWKTFSH
  1321  QFSEIKLLQD FYPWANHILL PSLYGDYRGK NAVLEPSHCK CGVQLIFQIP RTKTYEKVDE
  1381  GQLAFCDNGH TCGRPKSLFP GLHLRRFSYI CSPRPMVLIP TDELHERLTS KNENGFSYIM
  1441  RGAFFTSLRL ESFTSLQMSK KGCVWSIISQ VIYYLLVCYY AFIQGCQLKQ QKWRFFTGKR
  1501  NILDTSIILI SFILLGLDMK SISLHKKNMA RYRDDQDRFI SFYEAVKVNS AATHLVGFPV
  1561  LLATVQLWNL LRHSPRLRVI SRTLSRAWDE VVGFLLIILI LLTGYAIAFN LLFGCSISDY
  1621  RTFFSSAVTV VGLLMGISHQ EEVFALDPVL GTFLILTSVI LMVLVVINLF VSAILMAFGK
  1681  ERKSLKKEAA LIDTLLQKLS NLLGISWPQK TSSEQAATTA VGSDTEVLDE LP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PKD1L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
0.9 nTPM

Expression across tissuesHPA

Tissue

  • liver: 0.9 nTPM
  • pituitary gland: 0.3 nTPM
  • small intestine: 0.3 nTPM
  • testis: 0.3 nTPM
  • heart muscle: 0.2 nTPM
  • adipose tissue: 0.1 nTPM

Single-cell type

  • oocytes: 180 nCPM
  • epicardial cells: 98 nCPM
  • paneth cells: 85 nCPM
  • sertoli cells: 64 nCPM
  • lactotrophs: 26 nCPM
  • cardiomyocytes: 24 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.9 nTPM
  • cerebral cortex: 0.9 nTPM
  • pons: 0.7 nTPM
  • white matter: 0.7 nTPM
  • choroid plexus: 0.6 nTPM
  • hippocampal formation: 0.6 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PKD1L3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PKD1L3 as an antibody target. Whether an autoantibody or antibody against PKD1L3 could matter depends on whether native PKD1L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PKD1L3 is annotated at the cell surface, where native PKD1L3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PKD1L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PKD1L3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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