Seroatlas · Human Serome Atlas

KLRK1

NKG2-D type II integral membrane protein

Also known as: CD314, D12S2489E, KLR, NKG2-D, NKG2D, NKG2D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26718
Gene
KLRK1
Ensembl
ENSG00000213809
Chromosome
12
Canonical length
216 aa
Protein class
Cancer-related genes, CD markers, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>P26718|KLRK1
     1  MGWIRGRRSR HSWEMSEFHN YNLDLKKSDF STRWQKQRCP VVKSKCRENA SPFFFCCFIA
    61  VAMGIRFIIM VTIWSAVFLN SLFNQEVQIP LTESYCGPCP KNWICYKNNC YQFFDESKNW
   121  YESQASCMSQ NASLLKVYSK EDQDLLKLVK SYHWMGLVHI PTNGSWQWED GSILSPNLLT
   181  IIEMQKGDCA LYASSFKGYI ENCSTPNTYI CMQRTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 39 nTPM
  • lymph node: 35 nTPM
  • bone marrow: 21 nTPM
  • tonsil: 18 nTPM
  • appendix: 12 nTPM
  • small intestine: 11 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 25 nCPM
  • nk-cells: 23 nCPM
  • t-cells: 12 nCPM
  • oligodendrocytes: 8.3 nCPM
  • b-cells: 1.4 nCPM
  • bergmann glia: 0.9 nCPM

Immune cell

  • NK-cell: 336 nTPM
  • gdT-cell: 287 nTPM
  • memory CD8 T-cell: 260 nTPM
  • naive CD8 T-cell: 259 nTPM
  • total PBMC: 128 nTPM
  • MAIT T-cell: 111 nTPM

Brain region

  • white matter: 2.1 nTPM
  • medulla oblongata: 1.8 nTPM
  • cerebral cortex: 1.6 nTPM
  • basal ganglia: 1.4 nTPM
  • pons: 1.3 nTPM
  • spinal cord: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0
gnomAD missense Z
0.63

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLRK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRK1 as an antibody target. Whether an autoantibody or antibody against KLRK1 could matter depends on whether native KLRK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRK1 is annotated at the cell surface, where native KLRK1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KLRK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLRK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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