Seroatlas · Human Serome Atlas

CLEC4F

C-type lectin domain family 4 member F

Also known as: CLC4F_HUMAN, CLECSF13, FLJ39110, KCLR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1N0
Gene: CLEC4F
Ensembl: ENSG00000152672
Chromosome: 2
Canonical length: 589 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable galactose binding activity; glycolipid binding activity; and pattern recognition receptor activity. Predicted to be involved in immune response. Predicted to act upstream of or within NK T cell activation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>Q8N1N0|CLEC4F
     1  MDGEAVRFCT DNQCVSLHPQ EVDSVAMAPA APKIPRLVQA TPAFMAVTLV FSLVTLFVVV
    61  QQQTRPVPKP VQAVILGDNI TGHLPFEPNN HHHFGREAEM RELIQTFKGH MENSSAWVVE
   121  IQMLKCRVDN VNSQLQVLGD HLGNTNADIQ MVKGVLKDAT TLSLQTQMLR SSLEGTNAEI
   181  QRLKEDLEKA DALTFQTLNF LKSSLENTSI ELHVLSRGLE NANSEIQMLN ASLETANTQA
   241  QLANSSLKNA NAEIYVLRGH LDSVNDLRTQ NQVLRNSLEG ANAEIQGLKE NLQNTNALNS
   301  QTQAFIKSSF DNTSAEIQFL RGHLERAGDE IHVLKRDLKM VTAQTQKANG RLDQTDTQIQ
   361  VFKSEMENVN TLNAQIQVLN GHMKNASREI QTLKQGMKNA SALTSQTQML DSNLQKASAE
   421  IQRLRGDLEN TKALTMEIQQ EQSRLKTLHV VITSQEQLQR TQSQLLQMVL QGWKFNGGSL
   481  YYFSSVKKSW HEAEQFCVSQ GAHLASVASK EEQAFLVEFT SKVYYWIGLT DRGTEGSWRW
   541  TDGTPFNAAQ NKAPGSKGSC PLRKYIIVNS GMGACSFIDT PPCPWILSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC4F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

retina: 16 nTPM
small intestine: 4.2 nTPM
spleen: 3.2 nTPM
cervix: 1.6 nTPM
salivary gland: 1.6 nTPM
adipose tissue: 1.5 nTPM

Single-cell type

cdc: 22 nCPM
rod photoreceptor cells: 17 nCPM
cone photoreceptor cells: 12 nCPM
retinal ganglion cells: 7.7 nCPM
macrophages: 7.1 nCPM
retinal horizontal cells: 4 nCPM

Immune cell

intermediate monocyte: 6 nTPM
non-classical monocyte: 4.4 nTPM
myeloid DC: 0.4 nTPM
total PBMC: 0.3 nTPM
classical monocyte: 0.2 nTPM
basophil: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
cerebellum: 0.2 nTPM
hypothalamus: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

external side of plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC4F as an antibody target. Whether an autoantibody or antibody against CLEC4F could matter depends on whether native CLEC4F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC4F is annotated at the cell surface, where native CLEC4F is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC4F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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