Seroatlas · Human Serome Atlas

KLRC4

NKG2-F type II integral membrane protein

Also known as: NKG2-F, NKG2F_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43908
Gene
KLRC4
Ensembl
ENSG00000183542
Chromosome
12
Canonical length
158 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>O43908|KLRC4
     1  MNKQRGTYSE VSLAQDPKRQ QRKLKGNKIS ISGTKQEIFQ VELNLQNASS DHQGNDKTYH
    61  CKGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPCIGVL EQNNFSLNRR MQKARHCGHC
   121  PEEWITYSNS CYYIGKERRT WEERVCWPVL RRTLICFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
8.9 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 8.9 nTPM
  • lymph node: 4.4 nTPM
  • tonsil: 3.1 nTPM
  • cerebral cortex: 2.6 nTPM
  • small intestine: 2.5 nTPM
  • appendix: 2.2 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 15 nCPM
  • nk-cells: 3.9 nCPM
  • t-cells: 3.1 nCPM
  • oligodendrocytes: 1.6 nCPM
  • fibroblasts: 0.1 nCPM
  • macrophages: 0.1 nCPM

Immune cell

  • gdT-cell: 8.2 nTPM
  • naive CD8 T-cell: 6.8 nTPM
  • memory CD8 T-cell: 5.9 nTPM
  • NK-cell: 4.8 nTPM
  • total PBMC: 1.8 nTPM
  • MAIT T-cell: 0.3 nTPM

Brain region

  • white matter: 6.2 nTPM
  • medulla oblongata: 5.2 nTPM
  • cerebral cortex: 4.8 nTPM
  • basal ganglia: 4.7 nTPM
  • hypothalamus: 4.6 nTPM
  • amygdala: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.46
gnomAD pLI
0.01
gnomAD missense Z
0.51
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRC4 as an antibody target. Whether an autoantibody or antibody against KLRC4 could matter depends on whether native KLRC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRC4 is annotated at the cell surface, where native KLRC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • They can also regulate specific humoral and cell-mediated immunity.

Canonical record: https://seroatlas.com/gene/KLRC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...