Seroatlas · Human Serome Atlas

COLEC12

Collectin-12

Also known as: CL-P1, COL12_HUMAN, SCARA4, SRCL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5KU26
Gene
COLEC12
Ensembl
ENSG00000158270
Chromosome
18
Canonical length
742 aa
Protein class
Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018]

Canonical amino-acid sequenceUniProt

742 residues, UniProt reviewed canonical sequence.

>Q5KU26|COLEC12
     1  MKDDFAEEEE VQSFGYKRFG IQEGTQCTKC KNNWALKFSI ILLYILCALL TITVAILGYK
    61  VVEKMDNVTG GMETSRQTYD DKLTAVESDL KKLGDQTGKK AISTNSELST FRSDILDLRQ
   121  QLREITEKTS KNKDTLEKLQ ASGDALVDRQ SQLKETLENN SFLITTVNKT LQAYNGYVTN
   181  LQQDTSVLQG NLQNQMYSHN VVIMNLNNLN LTQVQQRNLI TNLQRSVDDT SQAIQRIKND
   241  FQNLQQVFLQ AKKDTDWLKE KVQSLQTLAA NNSALAKANN DTLEDMNSQL NSFTGQMENI
   301  TTISQANEQN LKDLQDLHKD AENRTAIKFN QLEERFQLFE TDIVNIISNI SYTAHHLRTL
   361  TSNLNEVRTT CTDTLTKHTD DLTSLNNTLA NIRLDSVSLR MQQDLMRSRL DTEVANLSVI
   421  MEEMKLVDSK HGQLIKNFTI LQGPPGPRGP RGDRGSQGPP GPTGNKGQKG EKGEPGPPGP
   481  AGERGPIGPA GPPGERGGKG SKGSQGPKGS RGSPGKPGPQ GSSGDPGPPG PPGKEGLPGP
   541  QGPPGFQGLQ GTVGEPGVPG PRGLPGLPGV PGMPGPKGPP GPPGPSGAVV PLALQNEPTP
   601  APEDNGCPPH WKNFTDKCYY FSVEKEIFED AKLFCEDKSS HLVFINTREE QQWIKKQMVG
   661  RESHWIGLTD SERENEWKWL DGTSPDYKNW KAGQPDNWGH GHGPGEDCAG LIYAGQWNDF
   721  QCEDVNNFIC EKDRETVLSS AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COLEC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 26 nTPM
  • placenta: 19 nTPM
  • choroid plexus: 16 nTPM
  • adipose tissue: 12 nTPM
  • lung: 11 nTPM
  • endometrium: 8.8 nTPM

Single-cell type

  • hofbauer cells: 863 nCPM
  • bergmann glia: 544 nCPM
  • cytotrophoblasts: 497 nCPM
  • macrophages: 388 nCPM
  • lymphatic endothelial cells: 383 nCPM
  • müller glia: 364 nCPM

Immune cell

  • neutrophil: 0.5 nTPM
  • basophil: 0.4 nTPM
  • classical monocyte: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • choroid plexus: 17 nTPM
  • medulla oblongata: 13 nTPM
  • hypothalamus: 12 nTPM
  • midbrain: 10 nTPM
  • thalamus: 10 nTPM
  • white matter: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.91
gnomAD missense Z
1.49
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COLEC12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COLEC12 as an antibody target. Whether an autoantibody or antibody against COLEC12 could matter depends on whether native COLEC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COLEC12 is annotated at the cell surface, where native COLEC12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label COLEC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COLEC12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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