Seroatlas · Human Serome Atlas

CLEC4G

C-type lectin domain family 4 member G

Also known as: CLC4G_HUMAN, LSECTIN, UNQ431

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXB4
Gene
CLEC4G
Ensembl
ENSG00000182566
Chromosome
19
Canonical length
293 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q6UXB4|CLEC4G
     1  MDTTRYSKWG GSSEEVPGGP WGRWVHWSRR PLFLALAVLV TTVLWAVILS ILLSKASTER
    61  AALLDGHDLL RTNASKQTAA LGALKEEVGD CHSCCSGTQA QLQTTRAELG EAQAKLMEQE
   121  SALRELRERV TQGLAEAGRG REDVRTELFR ALEAVRLQNN SCEPCPTSWL SFEGSCYFFS
   181  VPKTTWAAAQ DHCADASAHL VIVGGLDEQG FLTRNTRGRG YWLGLRAVRH LGKVQGYQWV
   241  DGVSLSFSHW NQGEPNDAWG RENCVMMLHT GLWNDAPCDS EKDGWICEKR HNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC4G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • liver: 51 nTPM
  • cerebellum: 21 nTPM
  • adipose tissue: 15 nTPM
  • lymph node: 15 nTPM
  • urinary bladder: 7.2 nTPM
  • hippocampal formation: 5.2 nTPM

Single-cell type

  • brain excitatory neurons: 10 nCPM
  • other brain neurons: 1.8 nCPM
  • brain inhibitory neurons: 1.6 nCPM
  • bergmann glia: 1.2 nCPM
  • kupffer cells: 1 nCPM
  • vascular endothelial cells: 0.3 nCPM

Immune cell

  • classical monocyte: 19 nTPM
  • myeloid DC: 15 nTPM
  • total PBMC: 4.5 nTPM
  • intermediate monocyte: 4.2 nTPM
  • naive B-cell: 4.2 nTPM
  • plasmacytoid DC: 0.7 nTPM

Brain region

  • hypothalamus: 5.1 nTPM
  • cerebellum: 4.5 nTPM
  • cerebral cortex: 2.7 nTPM
  • hippocampal formation: 1.7 nTPM
  • medulla oblongata: 1.3 nTPM
  • pons: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
0.62
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLEC4G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC4G as an antibody target. Whether an autoantibody or antibody against CLEC4G could matter depends on whether native CLEC4G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC4G is annotated at the cell surface, where native CLEC4G is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC4G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC4G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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