PLA2R1

Protein identityUniProt · HPA

UniProt accession

Q13018

Gene

PLA2R1

Ensembl

ENSG00000153246

Chromosome

2

Canonical length

1463 aa

Protein class

Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Cytosol

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

1463 residues, UniProt reviewed canonical sequence.

>Q13018|PLA2R1
     1  MLLSPSLLLL LLLGAPRGCA EGVAAALTPE RLLEWQDKGI FVIQSESLKK CIQAGKSVLT
    61  LENCKQANKH MLWKWVSNHG LFNIGGSGCL GLNFSAPEQP LSLYECDSTL VSLRWRCNRK
   121  MITGPLQYSV QVAHDNTVVA SRKYIHKWIS YGSGGGDICE YLHKDLHTIK GNTHGMPCMF
   181  PFQYNHQWHH ECTREGREDD LLWCATTSRY ERDEKWGFCP DPTSAEVGCD TIWEKDLNSH
   241  ICYQFNLLSS LSWSEAHSSC QMQGGTLLSI TDETEENFIR EHMSSKTVEV WMGLNQLDEH
   301  AGWQWSDGTP LNYLNWSPEV NFEPFVEDHC GTFSSFMPSA WRSRDCESTL PYICKKYLNH
   361  IDHEIVEKDA WKYYATHCEP GWNPYNRNCY KLQKEEKTWH EALRSCQADN SALIDITSLA
   421  EVEFLVTLLG DENASETWIG LSSNKIPVSF EWSNDSSVIF TNWHTLEPHI FPNRSQLCVS
   481  AEQSEGHWKV KNCEERLFYI CKKAGHVLSD AESGCQEGWE RHGGFCYKID TVLRSFDQAS
   541  SGYYCPPALV TITNRFEQAF ITSLISSVVK MKDSYFWIAL QDQNDTGEYT WKPVGQKPEP
   601  VQYTHWNTHQ PRYSGGCVAM RGRHPLGRWE VKHCRHFKAM SLCKQPVENQ EKAEYEERWP
   661  FHPCYLDWES EPGLASCFKV FHSEKVLMKR TWREAEAFCE EFGAHLASFA HIEEENFVNE
   721  LLHSKFNWTE ERQFWIGFNK RNPLNAGSWE WSDRTPVVSS FLDNTYFGED ARNCAVYKAN
   781  KTLLPLHCGS KREWICKIPR DVKPKIPFWY QYDVPWLFYQ DAEYLFHTFA SEWLNFEFVC
   841  SWLHSDLLTI HSAHEQEFIH SKIKALSKYG ASWWIGLQEE RANDEFRWRD GTPVIYQNWD
   901  TGRERTVNNQ SQRCGFISSI TGLWGSEECS VSMPSICKRK KVWLIEKKKD TPKQHGTCPK
   961  GWLYFNYKCL LLNIPKDPSS WKNWTHAQHF CAEEGGTLVA IESEVEQAFI TMNLFGQTTS
  1021  VWIGLQNDDY ETWLNGKPVV YSNWSPFDII NIPSHNTTEV QKHIPLCALL SSNPNFHFTG
  1081  KWYFEDCGKE GYGFVCEKMQ DTSGHGVNTS DMYPMPNTLE YGNRTYKIIN ANMTWYAAIK
  1141  TCLMHKAQLV SITDQYHQSF LTVVLNRLGY AHWIGLFTTD NGLNFDWSDG TKSSFTFWKD
  1201  EESSLLGDCV FADSNGRWHS TACESFLQGA ICHVPPETRQ SEHPELCSET SIPWIKFKSN
  1261  CYSFSTVLDS MSFEAAHEFC KKEGSNLLTI KDEAENAFLL EELFAFGSSV QMVWLNAQFD
  1321  GNNETIKWFD GTPTDQSNWG IRKPDTDYFK PHHCVALRIP EGLWQLSPCQ EKKGFICKME
  1381  ADIHTAEALP EKGPSHSIIP LAVVLTLIVI VAICTLSFCI YKHNGGFFRR LAGFRNPYYP
  1441  ATNFSTVYLE ENILISDLEK SDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

39 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLA2R1.

Disease | ImmuneIEDB

Conditions an epitope on PLA2R1 was assayed in.

• kidney disease T cell
• autoimmune glomerulonephritis B cell
• autoimmune disease of urogenital tract B cell
• IgA glomerulonephritis B cell
• autoimmune vasculitis B cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against PLA2R1 are reported. Each links to that disease's full target list.

• Glomerulonephritis, Membranous 290
• Proteinuria 47
• Nephrotic Syndrome 32
• Kidney Failure, Chronic 6
• Glomerulonephritis 5
• Lupus Nephritis 5
• Glomerulonephritis, IGA 4

Showing 7 of 8 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for PLA2R1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.87

gnomAD pLI

0

gnomAD missense Z

0.35

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• oxidative stress-induced premature senescence
• positive regulation of arachidonate secretion
• positive regulation of cytokine production
• positive regulation of DNA damage response, signal transduction by p53 class mediator
• positive regulation of podocyte apoptotic process
• reactive oxygen species metabolic process
• receptor-mediated endocytosis
• replicative senescence
• negative regulation of arachidonate secretion

Molecular functions

• carbohydrate binding
• phospholipase A2 inhibitor activity
• phospholipase binding
• signaling receptor activity

Cellular components

• cell surface
• extracellular region
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Fibronectin type II domain
• Ricin B, lectin domain
• C-type lectin-like
• C-type lectin-like/link domain superfamily
• C-type lectin fold
• C-type lectin, conserved site
• Ricin B-like lectins
• Fibronectin type II domain superfamily
• C-type lectin and snaclec domain-containing protein
• Fibronectin type II domain
• Lectin C-type domain
• MRC2-like, N-terminal cysteine-rich domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Endocytosis
• Glycoprotein
• Lectin
• Membrane
• Receptor
• Repeat
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of PLA2R1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PLA2G10
• PLA2G1B