Seroatlas · Human Serome Atlas

CD93

Complement component C1q receptor

Also known as: C1qR(P), C1QR1, C1QR1_HUMAN, C1qRP, CDw93, dJ737E23.1, ECSM3, MXRA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPY3
Gene: CD93
Ensembl: ENSG00000125810
Chromosome: 20
Canonical length: 652 aa
Protein class: CD markers, Plasma proteins, Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q9NPY3|CD93
     1  MATSMGLLLL LLLLLTQPGA GTGADTEAVV CVGTACYTAH SGKLSAAEAQ NHCNQNGGNL
    61  ATVKSKEEAQ HVQRVLAQLL RREAALTARM SKFWIGLQRE KGKCLDPSLP LKGFSWVGGG
   121  EDTPYSNWHK ELRNSCISKR CVSLLLDLSQ PLLPSRLPKW SEGPCGSPGS PGSNIEGFVC
   181  KFSFKGMCRP LALGGPGQVT YTTPFQTTSS SLEAVPFASA ANVACGEGDK DETQSHYFLC
   241  KEKAPDVFDW GSSGPLCVSP KYGCNFNNGG CHQDCFEGGD GSFLCGCRPG FRLLDDLVTC
   301  ASRNPCSSSP CRGGATCVLG PHGKNYTCRC PQGYQLDSSQ LDCVDVDECQ DSPCAQECVN
   361  TPGGFRCECW VGYEPGGPGE GACQDVDECA LGRSPCAQGC TNTDGSFHCS CEEGYVLAGE
   421  DGTQCQDVDE CVGPGGPLCD SLCFNTQGSF HCGCLPGWVL APNGVSCTMG PVSLGPPSGP
   481  PDEEDKGEKE GSTVPRAATA SPTRGPEGTP KATPTTSRPS LSSDAPITSA PLKMLAPSGS
   541  PGVWREPSIH HATAASGPQE PAGGDSSVAT QNNDGTDGQK LLLFYILGTV VAILLLLALA
   601  LGLLVYRKRR AKREEKKEKK PQNAADSYSW VPERAESRAM ENQYSPTPGT DC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD93 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 129 nTPM

Expression across tissuesHPA

Tissue

placenta: 129 nTPM
adipose tissue: 76 nTPM
lung: 61 nTPM
appendix: 41 nTPM
smooth muscle: 41 nTPM
breast: 40 nTPM

Single-cell type

vascular endothelial cells: 307 nCPM
monocytes: 261 nCPM
neutrophils: 208 nCPM
kupffer cells: 154 nCPM
neutrophil progenitors: 133 nCPM
macrophages: 99 nCPM

Immune cell

neutrophil: 28 nTPM
classical monocyte: 26 nTPM
intermediate monocyte: 17 nTPM
total PBMC: 9.9 nTPM
myeloid DC: 9.1 nTPM
non-classical monocyte: 7.5 nTPM

Brain region

thalamus: 15 nTPM
cerebral cortex: 14 nTPM
choroid plexus: 13 nTPM
pons: 11 nTPM
medulla oblongata: 11 nTPM
spinal cord: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD93 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD93 as an antibody target. Whether an autoantibody or antibody against CD93 could matter depends on whether native CD93 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD93 is annotated at the cell surface, where native CD93 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD93 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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