Seroatlas · Human Serome Atlas

REG3G

Regenerating islet-derived protein 3-gamma

Also known as: LPPM429, PAP1B, REG3G_HUMAN, UNQ429

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UW15
Gene: REG3G
Ensembl: ENSG00000143954
Chromosome: 2
Canonical length: 175 aa
Protein class: Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q6UW15|REG3G
     1  MLPPMALPSV SWMLLSCLIL LCQVQGEETQ KELPSPRISC PKGSKAYGSP CYALFLSPKS
    61  WMDADLACQK RPSGKLVSVL SGAEGSFVSS LVRSISNSYS YIWIGLHDPT QGSEPDGDGW
   121  EWSSTDVMNY FAWEKNPSTI LNPGHCGSLS RSTGFLKWKD YNCDAKLPYV CKFKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REG3G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 3,450 nTPM

Expression across tissuesHPA

Tissue

pancreas: 3,450 nTPM
epididymis: 156 nTPM
testis: 59 nTPM
adrenal gland: 43 nTPM
small intestine: 37 nTPM
kidney: 6.8 nTPM

Single-cell type

pancreatic acinar cells: 7,001 nCPM
sertoli cells: 103 nCPM
epididymal principal cells: 66 nCPM
enterocytes: 38 nCPM
paneth cells: 27 nCPM
granulosa cells: 15 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: -0.93
DepMap mean gene effect: 0.19
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of REG3G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EXTL3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REG3G as an antibody target. Whether an autoantibody or antibody against REG3G could matter depends on whether native REG3G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REG3G is annotated as secreted, so native REG3G circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label REG3G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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