Seroatlas · Human Serome Atlas

CLEC10A

C-type lectin domain family 10 member A

Also known as: CD301, CLC10_HUMAN, CLECSF13, CLECSF14, HML, HML2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUN9
Gene
CLEC10A
Ensembl
ENSG00000132514
Chromosome
17
Canonical length
316 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q8IUN9|CLEC10A
     1  MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL LLVIICVVGF
    61  QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET IASLKAEVEG FKQERQAGVS
   121  ELQEHTTQKA HLGHCPHCPS VCVPVHSEML LRVQQLVQDL KKLTCQVATL NNNASTEGTC
   181  CPVNWVEHQD SCYWFSHSGM SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG
   241  LSDPEGAWKW VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY
   301  HWVCEAGLGQ TSQESH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • appendix: 28 nTPM
  • small intestine: 24 nTPM
  • adipose tissue: 20 nTPM
  • urinary bladder: 19 nTPM
  • lymph node: 19 nTPM
  • gallbladder: 18 nTPM

Single-cell type

  • cdc: 663 nCPM
  • macrophages: 125 nCPM
  • monocytes: 77 nCPM
  • hofbauer cells: 11 nCPM
  • kupffer cells: 6.1 nCPM
  • undifferentiated spermatogonia: 3.7 nCPM

Immune cell

  • myeloid DC: 467 nTPM
  • intermediate monocyte: 39 nTPM
  • classical monocyte: 30 nTPM
  • total PBMC: 21 nTPM
  • plasmacytoid DC: 9.3 nTPM
  • neutrophil: 2.2 nTPM

Brain region

  • choroid plexus: 2.8 nTPM
  • pons: 2.2 nTPM
  • cerebral cortex: 0.8 nTPM
  • thalamus: 0.8 nTPM
  • white matter: 0.6 nTPM
  • basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
0.36
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLEC10A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC10A as an antibody target. Whether an autoantibody or antibody against CLEC10A could matter depends on whether native CLEC10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC10A is annotated at the cell surface, where native CLEC10A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC10A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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