Seroatlas · Human Serome Atlas

KLRG2

Killer cell lectin-like receptor subfamily G member 2

Also known as: CLEC15B, FLJ44186, KLRG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D1S0
Gene: KLRG2
Ensembl: ENSG00000188883
Chromosome: 7
Canonical length: 409 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>A4D1S0|KLRG2
     1  MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP AGAVEKAAGA
    61  GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL VKLPRNGEAP GAEPAPSAWA
   121  PMELQVDVRV KPVGAAGGSS TPSPRPSTRF LKVPVPESPA FSRHADPAHQ LLLRAPSQGG
   181  TWGRRSPLAA ARTESGCDAE GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD
   241  GDEKLPRAVT LTGLPMYVKS LYWALAFMAV LLAVSGVVIV VLASRAGARC QQCPPGWVLS
   301  EEHCYYFSAE AQAWEASQAF CSAYHATLPL LSHTQDFLGR YPVSRHSWVG AWRGPQGWHW
   361  IDEAPLPPQL LPEDGEDNLD INCGALEEGT LVAANCSTPR PWVCAKGTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

kidney: 4.7 nTPM
salivary gland: 4.1 nTPM
thyroid gland: 3.8 nTPM
esophagus: 3.7 nTPM
lung: 2.8 nTPM
skin: 2.7 nTPM

Single-cell type

loop of henle epithelial cells: 109 nCPM
renal collecting duct principal cells: 35 nCPM
proximal tubule cells: 33 nCPM
alveolar cells type 1: 30 nCPM
esophageal basal cells: 19 nCPM
esophageal suprabasal cells: 13 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.1 nTPM
hypothalamus: 0.9 nTPM
medulla oblongata: 0.4 nTPM
white matter: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carbohydrate binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

C-type lectin-like
C-type lectin-like/link domain superfamily
C-type lectin fold
Natural killer cell receptor-like, C-type lectin-like domain
Lectin C-type domain
Killer cell lectin-like receptor subfamily G member 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRG2 as an antibody target. Whether an autoantibody or antibody against KLRG2 could matter depends on whether native KLRG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLRG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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