Seroatlas · Human Serome Atlas

CLEC4A

C-type lectin domain family 4 member A

Also known as: CD367, CLC4A_HUMAN, CLECSF6, DCIR, DDB27, hDCIR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UMR7
Gene
CLEC4A
Ensembl
ENSG00000111729
Chromosome
12
Canonical length
237 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q9UMR7|CLEC4A
     1  MTSEITYAEV RFKNEFKSSG INTASSAASK ERTAPHKSNT GFPKLLCASL LIFFLLLAIS
    61  FFIAFVIFFQ KYSQLLEKKT TKELVHTTLE CVKKNMPVEE TAWSCCPKNW KSFSSNCYFI
   121  STESASWQDS EKDCARMEAH LLVINTQEEQ DFIFQNLQEE SAYFVGLSDP EGQRHWQWVD
   181  QTPYNESSTF WHPREPSDPN ERCVVLNFRK SPKRWGWNDV NCLGPQRSVC EMMKIHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • appendix: 25 nTPM
  • bone marrow: 20 nTPM
  • spleen: 15 nTPM
  • lung: 10 nTPM
  • lymph node: 8.8 nTPM
  • tonsil: 8.3 nTPM

Single-cell type

  • microglia: 15 nCPM
  • podocytes: 10 nCPM
  • monocytes: 6.5 nCPM
  • astrocytes: 4.4 nCPM
  • neutrophils: 4.3 nCPM
  • oligodendrocyte progenitor cells: 4.2 nCPM

Immune cell

  • classical monocyte: 333 nTPM
  • myeloid DC: 328 nTPM
  • neutrophil: 300 nTPM
  • basophil: 228 nTPM
  • intermediate monocyte: 199 nTPM
  • total PBMC: 169 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • medulla oblongata: 7.7 nTPM
  • white matter: 5.9 nTPM
  • midbrain: 5.6 nTPM
  • spinal cord: 5.6 nTPM
  • cerebellum: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
0.55
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC4A as an antibody target. Whether an autoantibody or antibody against CLEC4A could matter depends on whether native CLEC4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC4A is annotated at the cell surface, where native CLEC4A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC4A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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