Seroatlas · Human Serome Atlas

KLRB1

Killer cell lectin-like receptor subfamily B member 1

Also known as: CD161, CLEC5B, hNKR-P1A, KLRB1_HUMAN, NKR, NKR-P1, NKR-P1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12918
Gene
KLRB1
Ensembl
ENSG00000111796
Chromosome
12
Canonical length
225 aa
Protein class
CD markers, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q12918|KLRB1
     1  MDQQAIYAEL NLPTDSGPES SSPSSLPRDV CQGSPWHQFA LKLSCAGIIL LVLVVTGLSV
    61  SVTSLIQKSS IEKCSVDIQQ SRNKTTERPG LLNCPIYWQQ LREKCLLFSH TVNPWNNSLA
   121  DCSTKESSLL LIRDKDELIH TQNLIRDKAI LFWIGLNFSL SEKNWKWING SFLNSNDLEI
   181  RGDAKENSCI SISQTSVYSE YCSTEIRWIC QKELTPVRNK VYPDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 45 nTPM
  • tonsil: 34 nTPM
  • spleen: 27 nTPM
  • small intestine: 19 nTPM
  • lymph node: 19 nTPM
  • appendix: 17 nTPM

Single-cell type

  • innate lymphoid cells: 955 nCPM
  • nk-cells: 951 nCPM
  • t-cells: 644 nCPM
  • hematopoietic stem cells: 25 nCPM
  • pdcs: 22 nCPM
  • kupffer cells: 18 nCPM

Immune cell

  • MAIT T-cell: 2,181 nTPM
  • NK-cell: 758 nTPM
  • gdT-cell: 521 nTPM
  • memory CD8 T-cell: 346 nTPM
  • memory CD4 T-cell: 308 nTPM
  • total PBMC: 285 nTPM

Brain region

  • cerebral cortex: 1.7 nTPM
  • white matter: 1.7 nTPM
  • basal ganglia: 1.6 nTPM
  • hypothalamus: 1.5 nTPM
  • amygdala: 1.4 nTPM
  • medulla oblongata: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.44
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLRB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRB1 as an antibody target. Whether an autoantibody or antibody against KLRB1 could matter depends on whether native KLRB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRB1 is annotated at the cell surface, where native KLRB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KLRB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLRB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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