Seroatlas · Human Serome Atlas

REG3A

Regenerating islet-derived protein 3-alpha

Also known as: HIP, PAP, PAP1, PBCGF, REG-III, REG3, REG3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q06141
Gene: REG3A
Ensembl: ENSG00000172016
Chromosome: 2
Canonical length: 175 aa
Protein class: Plasma proteins, Predicted secreted proteins, Transporters
Subcellular location: Cytosol
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q06141|REG3A
     1  MLPPMALPSV SWMLLSCLML LSQVQGEEPQ RELPSARIRC PKGSKAYGSH CYALFLSPKS
    61  WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW
   121  EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCNVRLPYV CKFTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REG3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 11,382 nTPM

Expression across tissuesHPA

Tissue

pancreas: 11,382 nTPM
small intestine: 6,346 nTPM
duodenum: 4,867 nTPM
stomach: 143 nTPM
gallbladder: 23 nTPM
adipose tissue: 16 nTPM

Single-cell type

pancreatic acinar cells: 30,200 nCPM
paneth cells: 26,496 nCPM
mucous neck cells: 1,411 nCPM
gastric chief cells: 126 nCPM
pancreatic duct cells: 87 nCPM
goblet cells: 45 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of REG3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EXTL3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REG3A as an antibody target. Whether an autoantibody or antibody against REG3A could matter depends on whether native REG3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REG3A is annotated as secreted, so native REG3A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label REG3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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