Seroatlas · Human Serome Atlas

CD302

CD302 antigen

Also known as: BIMLEC, CD302_HUMAN, CLEC13A, DCL-1, KIAA0022

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IX05
Gene: CD302
Ensembl: ENSG00000241399
Chromosome: 2
Canonical length: 232 aa
Protein class: CD markers, Predicted membrane proteins

OverviewNCBI Gene

CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008]

Canonical amino-acid sequenceUniProt

232 residues, UniProt reviewed canonical sequence.

>Q8IX05|CD302
     1  MLRAALPALL LPLLGLAAAA VADCPSSTWI QFQDSCYIFL QEAIKVESIE DVRNQCTDHG
    61  ADMISIHNEE ENAFILDTLK KQWKGPDDIL LGMFYDTDDA SFKWFDNSNM TFDKWTDQDD
   121  DEDLVDTCAF LHIKTGEWKK GNCEVSSVEG TLCKTAIPYK RKYLSDNHIL ISALVIASTV
   181  ILTVLGAIIW FLYKKHSDSR FTTVFSTAPQ SPYNEDCVLV VGEENEYPVQ FD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD302 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 181 nTPM

Expression across tissuesHPA

Tissue

liver: 181 nTPM
lung: 47 nTPM
adipose tissue: 46 nTPM
ovary: 46 nTPM
blood vessel: 36 nTPM
cervix: 33 nTPM

Single-cell type

kupffer cells: 432 nCPM
hepatocytes: 243 nCPM
monocytes: 224 nCPM
monocyte progenitors: 187 nCPM
neutrophils: 151 nCPM
macrophages: 145 nCPM

Immune cell

classical monocyte: 33 nTPM
eosinophil: 32 nTPM
neutrophil: 29 nTPM
non-classical monocyte: 26 nTPM
myeloid DC: 25 nTPM
intermediate monocyte: 24 nTPM

Brain region

choroid plexus: 17 nTPM
medulla oblongata: 13 nTPM
white matter: 13 nTPM
hypothalamus: 11 nTPM
spinal cord: 10 nTPM
pons: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phagocytosis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD302 as an antibody target. Whether an autoantibody or antibody against CD302 could matter depends on whether native CD302 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD302 is annotated at the cell surface, where native CD302 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD302 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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