Seroatlas · Human Serome Atlas

KLRC1

NKG2-A/NKG2-B type II integral membrane protein

Also known as: CD159a, NKG2, NKG2-A, NKG2-B, NKG2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26715
Gene
KLRC1
Ensembl
ENSG00000134545
Chromosome
12
Canonical length
233 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>P26715|KLRC1
     1  MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ DFQGNDKTYH
    61  CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR HNNSSLNTRT QKARHCGHCP
   121  EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN
   181  SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
6.2 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 6.2 nTPM
  • bone marrow: 4.9 nTPM
  • stomach: 4 nTPM
  • lung: 3.1 nTPM
  • endometrium: 2.9 nTPM
  • lymph node: 2.9 nTPM

Single-cell type

  • nk-cells: 283 nCPM
  • t-cells: 107 nCPM
  • innate lymphoid cells: 45 nCPM
  • goblet cells: 9.7 nCPM
  • gastric chief cells: 5.5 nCPM
  • pdcs: 5.1 nCPM

Immune cell

  • NK-cell: 369 nTPM
  • gdT-cell: 230 nTPM
  • memory CD8 T-cell: 40 nTPM
  • naive CD8 T-cell: 33 nTPM
  • MAIT T-cell: 29 nTPM
  • total PBMC: 29 nTPM

Brain region

  • white matter: 9.7 nTPM
  • thalamus: 9.1 nTPM
  • cerebral cortex: 8.5 nTPM
  • hypothalamus: 8.5 nTPM
  • medulla oblongata: 8.5 nTPM
  • pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
-0.07
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLRC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRC1 as an antibody target. Whether an autoantibody or antibody against KLRC1 could matter depends on whether native KLRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRC1 is annotated at the cell surface, where native KLRC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • They can also regulate specific humoral and cell-mediated immunity.

Canonical record: https://seroatlas.com/gene/KLRC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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