Seroatlas · Human Serome Atlas

TNFAIP6

Tumor necrosis factor-inducible gene 6 protein

Also known as: TSG-6, TSG6, TSG6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P98066
Gene
TNFAIP6
Ensembl
ENSG00000123610
Chromosome
2
Canonical length
277 aa
Protein class
Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>P98066|TNFAIP6
     1  MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF
    61  EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS
   121  ERWDAYCYNP HAKECGGVFT DPKQIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF
   181  DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF
   241  QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFAIP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
182 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 182 nTPM
  • appendix: 26 nTPM
  • gallbladder: 19 nTPM
  • heart muscle: 15 nTPM
  • adipose tissue: 15 nTPM
  • lung: 12 nTPM

Single-cell type

  • neutrophils: 2,233 nCPM
  • early spermatids: 568 nCPM
  • monocytes: 382 nCPM
  • fibroblasts: 295 nCPM
  • late primary spermatocytes: 203 nCPM
  • neutrophil progenitors: 169 nCPM

Immune cell

  • neutrophil: 184 nTPM
  • classical monocyte: 8.2 nTPM
  • total PBMC: 2.5 nTPM
  • non-classical monocyte: 2.2 nTPM
  • intermediate monocyte: 1.8 nTPM
  • myeloid DC: 0.3 nTPM

Brain region

  • thalamus: 3.6 nTPM
  • white matter: 2.5 nTPM
  • basal ganglia: 2.4 nTPM
  • hypothalamus: 2.3 nTPM
  • midbrain: 2.3 nTPM
  • pons: 1.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNFAIP6.

Disease | ImmuneIEDB

Conditions an epitope on TNFAIP6 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFAIP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFAIP6 as an antibody target. Whether an autoantibody or antibody against TNFAIP6 could matter depends on whether native TNFAIP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFAIP6 is annotated as secreted, so native TNFAIP6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TNFAIP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNFAIP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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