Seroatlas · Human Serome Atlas

CLEC4E

C-type lectin domain family 4 member E

Also known as: CLC4E_HUMAN, CLECSF9, MINCLE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULY5
Gene
CLEC4E
Ensembl
ENSG00000166523
Chromosome
12
Canonical length
219 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q9ULY5|CLEC4E
     1  MNSSKSSETQ CTERGCFSSQ MFLWTVAGIP ILFLSACFIT RCVVTFRIFQ TCDEKKFQLP
    61  ENFTELSCYN YGSGSVKNCC PLNWEYFQSS CYFFSTDTIS WALSLKNCSA MGAHLVVINS
   121  QEEQEFLSYK KPKMREFFIG LSDQVVEGQW QWVDGTPLTK SLSFWDVGEP NNIATLEDCA
   181  TMRDSSNPRQ NWNDVTCFLN YFRICEMVGI NPLNKGKSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC4E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 72 nTPM
  • spleen: 51 nTPM
  • appendix: 35 nTPM
  • lung: 22 nTPM
  • choroid plexus: 22 nTPM
  • adipose tissue: 12 nTPM

Single-cell type

  • neutrophils: 1,575 nCPM
  • monocytes: 221 nCPM
  • neutrophil progenitors: 134 nCPM
  • macrophages: 105 nCPM
  • kupffer cells: 104 nCPM
  • cdc: 76 nCPM

Immune cell

  • neutrophil: 452 nTPM
  • classical monocyte: 129 nTPM
  • total PBMC: 30 nTPM
  • intermediate monocyte: 18 nTPM
  • myeloid DC: 17 nTPM
  • non-classical monocyte: 0.7 nTPM

Brain region

  • cerebral cortex: 14 nTPM
  • white matter: 13 nTPM
  • hypothalamus: 13 nTPM
  • choroid plexus: 13 nTPM
  • basal ganglia: 12 nTPM
  • hippocampal formation: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLEC4E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC4E as an antibody target. Whether an autoantibody or antibody against CLEC4E could matter depends on whether native CLEC4E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC4E is annotated at the cell surface, where native CLEC4E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC4E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC4E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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