CLEC11A
C-type lectin domain family 11 member A
Also known as: CLC11_HUMAN, CLECSF3, LSLCL, P47, SCGF
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y240
- Gene
- CLEC11A
- Ensembl
- ENSG00000105472
- Chromosome
- 19
- Canonical length
- 323 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Subcellular location
- Centrosome
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
323 residues, UniProt reviewed canonical sequence.
>Q9Y240|CLEC11A
1 MQAAWLLGAL VVPQLLGFGH GARGAEREWE GGWGGAQEEE REREALMLKH LQEALGLPAG
61 RGDENPAGTV EGKEDWEMEE DQGEEEEEEA TPTPSSGPSP SPTPEDIVTY ILGRLAGLDA
121 GLHQLHVRLH ALDTRVVELT QGLRQLRNAA GDTRDAVQAL QEAQGRAERE HGRLEGCLKG
181 LRLGHKCFLL SRDFEAQAAA QARCTARGGS LAQPADRQQM EALTRYLRAA LAPYNWPVWL
241 GVHDRRAEGL YLFENGQRVS FFAWHRSPRP ELGAQPSASP HPLSPDQPNG GTLENCVAQA
301 SDDGSWWDHD CQRRLYYVCE FPFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CLEC11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 109 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 109 nTPM
- cervix: 51 nTPM
- fallopian tube: 34 nTPM
- ovary: 31 nTPM
- endometrium: 28 nTPM
- vagina: 27 nTPM
Single-cell type
- epididymal efferent duct absorptive cells: 397 nCPM
- monocyte progenitors: 172 nCPM
- hepatic stellate cells: 161 nCPM
- megakaryocyte progenitors: 155 nCPM
- decidual stromal cells: 139 nCPM
- megakaryocyte-erythroid progenitors: 117 nCPM
Immune cell
- classical monocyte: 24 nTPM
- myeloid DC: 18 nTPM
- intermediate monocyte: 11 nTPM
- total PBMC: 8.1 nTPM
- NK-cell: 5.7 nTPM
- non-classical monocyte: 5.6 nTPM
Brain region
- medulla oblongata: 21 nTPM
- cerebral cortex: 18 nTPM
- pons: 17 nTPM
- midbrain: 17 nTPM
- cerebellum: 16 nTPM
- spinal cord: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.12
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.41
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CLEC11A as an antibody target. Whether an autoantibody or antibody against CLEC11A could matter depends on whether native CLEC11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CLEC11A is annotated as secreted, so native CLEC11A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CLEC11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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