Seroatlas · Human Serome Atlas

CLEC20A

Putative C-type lectin domain family 20 member A

Also known as: CL20A_HUMAN, FLJ44005, LINC00083, NCRNA00083, RP4-593C16.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZU45
Gene: CLEC20A
Ensembl: ENSG00000188585
Chromosome: 1
Canonical length: 400 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q6ZU45|CLEC20A
     1  MLPRALLLSF CAAALQLVSS KRDLVLVKEA LSWYDAQQHC RLHYTDLADL QPSGLWKLYS
    61  LMTSTPAWIG LFFDASTSGL RWSSGSTFTA LEWGQKLPEF GVGFCATLYT WLKLPSIGAA
   121  SCTAQKPFLC YCDPDVGHLI STKPSLSLTT SPKPAVVQIS GQTFMRFDQV MTWSSALLYC
   181  RSHHTDLADL QMVTDETGKE ALRSIMSETE AWIGLYLNAN SGSLSWSSDL GASIPSWLQV
   241  PMMVRGLCTA LGIYMTYSPK VYSVNCSSLL PFFCFYDSST GHRASAELPP LFHTSPTEMT
   301  EETTPRPGRA VASVGSGTDR RDTAAATEAQ HLSSESKEKT SAQKSGHPFG ILKADFTIST
   361  LMDPEEMKDQ FLRQIQEVLK LTLGHEQFRL KWVSFEVNKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC20A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

testis: 2.9 nTPM
lymph node: 1.1 nTPM
bone marrow: 0.8 nTPM
tonsil: 0.7 nTPM
spleen: 0.4 nTPM
kidney: 0.3 nTPM

Single-cell type

early spermatids: 34 nCPM
rod photoreceptor cells: 31 nCPM
cardiomyocytes: 27 nCPM
retinal ganglion cells: 27 nCPM
cone photoreceptor cells: 27 nCPM
hepatic stellate cells: 26 nCPM

Immune cell

naive B-cell: 11 nTPM
memory B-cell: 3.2 nTPM
non-classical monocyte: 1.6 nTPM
plasmacytoid DC: 0.4 nTPM
myeloid DC: 0.3 nTPM
total PBMC: 0.2 nTPM

Brain region

cerebral cortex: 0.7 nTPM
white matter: 0.5 nTPM
hippocampal formation: 0.4 nTPM
hypothalamus: 0.4 nTPM
basal ganglia: 0.3 nTPM
pons: 0.3 nTPM

OntologyGO

Molecular functions

carbohydrate binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC20A as an antibody target. Whether an autoantibody or antibody against CLEC20A could matter depends on whether native CLEC20A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC20A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLEC20A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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