Seroatlas · Human Serome Atlas

COLEC11

Collectin-11

Also known as: CL-11, CL-K1, COL11_HUMAN, MGC3279

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWP8
Gene: COLEC11
Ensembl: ENSG00000118004
Chromosome: 2
Canonical length: 271 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homotrimer

OverviewNCBI Gene

This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q9BWP8|COLEC11
     1  MRGNLALVGV LISLAFLSLL PSGHPQPAGD DACSVQILVP GLKGDAGEKG DKGAPGRPGR
    61  VGPTGEKGDM GDKGQKGSVG RHGKIGPIGS KGEKGDSGDI GPPGPNGEPG LPCECSQLRK
   121  AIGEMDNQVS QLTSELKFIK NAVAGVRETE SKIYLLVKEE KRYADAQLSC QGRGGTLSMP
   181  KDEAANGLMA AYLAQAGLAR VFIGINDLEK EGAFVYSDHS PMRTFNKWRS GEPNNAYDEE
   241  DCVEMVASGG WNDVACHTTM YFMCEFDKEN M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COLEC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

liver: 109 nTPM
gallbladder: 51 nTPM
ovary: 51 nTPM
heart muscle: 37 nTPM
choroid plexus: 33 nTPM
adrenal gland: 32 nTPM

Single-cell type

hepatic stellate cells: 813 nCPM
ovarian stromal cells: 149 nCPM
decidual stromal cells: 148 nCPM
pericytes: 64 nCPM
peritubular myoid cells: 50 nCPM
oocytes: 41 nCPM

Immune cell

neutrophil: 0.8 nTPM
basophil: 0.6 nTPM
naive CD4 T-cell: 0.4 nTPM
eosinophil: 0.3 nTPM
NK-cell: 0.3 nTPM
naive B-cell: 0.2 nTPM

Brain region

choroid plexus: 23 nTPM
cerebellum: 19 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 12 nTPM
pons: 12 nTPM
hippocampal formation: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COLEC11.

Disease | AllUniProt

Conditions COLEC11 is implicated in, by any mechanism.

3MC syndrome 2 (3MC2) MIM:265050

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 139 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

3MC syndrome 2
Malignant tumor of urinary bladder
3MC syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.02
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COLEC11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MASP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COLEC11 as an antibody target. Whether an autoantibody or antibody against COLEC11 could matter depends on whether native COLEC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COLEC11 is annotated as secreted, so native COLEC11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label COLEC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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