CHODL
Chondrolectin
Also known as: C21orf68, CHODL_HUMAN, FLJ12627, MT75, PRED12
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H9P2
- Gene
- CHODL
- Ensembl
- ENSG00000154645
- Chromosome
- 21
- Canonical length
- 273 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Centrosome,Cytosol
OverviewNCBI Gene
This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Canonical amino-acid sequenceUniProt
273 residues, UniProt reviewed canonical sequence.
>Q9H9P2|CHODL
1 MSRVVSLLLG AALLCGHGAF CRRVVSGQKV CFADFKHPCY KMAYFHELSS RVSFQEARLA
61 CESEGGVLLS LENEAEQKLI ESMLQNLTKP GTGISDGDFW IGLWRNGDGQ TSGACPDLYQ
121 WSDGSNSQYR NWYTDEPSCG SEKCVVMYHQ PTANPGLGGP YLYQWNDDRC NMKHNYICKY
181 EPEINPTAPV EKPYLTNQPG DTHQNVVVTE AGIIPNLIYV VIPTIPLLLL ILVAFGTCCF
241 QMLHKSKGRT KTSPNQSTLW ISKSTRKESG MEVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CHODL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- testis: 29 nTPM
- spleen: 13 nTPM
- hypothalamus: 7.8 nTPM
- prostate: 5.2 nTPM
- heart muscle: 3.5 nTPM
- kidney: 3.3 nTPM
Single-cell type
- sertoli cells: 278 nCPM
- gonadotrophs: 133 nCPM
- leydig cells: 104 nCPM
- plasma cells: 82 nCPM
- pituitary stem cells: 79 nCPM
- breast lactating cells: 73 nCPM
Immune cell
- MAIT T-cell: 1.5 nTPM
- naive CD8 T-cell: 0.3 nTPM
- T-reg: 0.3 nTPM
- gdT-cell: 0.2 nTPM
- memory CD8 T-cell: 0.2 nTPM
- plasmacytoid DC: 0.2 nTPM
Brain region
- medulla oblongata: 26 nTPM
- pons: 24 nTPM
- hypothalamus: 22 nTPM
- white matter: 8.4 nTPM
- midbrain: 6.2 nTPM
- thalamus: 6.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.36
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.05
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CHODL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CHODL as an antibody target. Whether an autoantibody or antibody against CHODL could matter depends on whether native CHODL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CHODL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CHODL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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