SELL

Protein identityUniProt · HPA

UniProt accession

P14151

Gene

SELL

Ensembl

ENSG00000188404

Chromosome

1

Canonical length

372 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>P14151|SELL
     1  MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW QRARRFCRDN
    61  YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW VGTNKSLTEE AENWGDGEPN
   121  NKKNKEDCVE IYIKRNKDAG KWNDDACHKL KAALCYTASC QPWSCSGHGE CVEIINNYTC
   181  NCDVGYYGPQ CQFVIQCEPL EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT
   241  CGPFGNWSSP EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK
   301  TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF IIWLARRLKK
   361  GKKSKRSMND PY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

217 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for SELL from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.01

gnomAD pLI

0

gnomAD missense Z

0.32

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
• cell adhesion
• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
• leukocyte cell-cell adhesion
• leukocyte tethering or rolling
• response to cytokine

Molecular functions

• calcium ion binding
• carbohydrate binding
• glycosphingolipid binding
• heparin binding
• oligosaccharide binding
• protease binding
• sialic acid binding

Cellular components

• external side of plasma membrane
• extracellular space
• plasma membrane
• secretory granule membrane

Protein domainsUniProt · Pfam · InterPro

• Sushi/SCR/CCP domain
• EGF-like domain
• C-type lectin-like
• Selectin superfamily
• C-type lectin-like/link domain superfamily
• C-type lectin fold
• C-type lectin, conserved site
• Selectin, C-type lectin-like domain
• Sushi/SCR/CCP superfamily
• Complement & Cell Adhesion Regulators
• EGF-like domain
• Lectin C-type domain
• Sushi repeat (SCR repeat)
• L-selectin

KeywordsUniProt

• Alternative initiation
• Calcium
• Cell adhesion
• Cell membrane
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Lectin
• Membrane
• Metal-binding
• Repeat
• Signal
• Sushi
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SELL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PODXL2