Seroatlas · Human Serome Atlas

CLEC18B

C-type lectin domain family 18 member B

Also known as: CL18B_HUMAN, MRCL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXF7
Gene: CLEC18B
Ensembl: ENSG00000140839
Chromosome: 16
Canonical length: 455 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable polysaccharide binding activity. Predicted to be located in Golgi apparatus; endosome; and sarcoplasmic reticulum. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>Q6UXF7|CLEC18B
     1  MLHPETSPGR GHLLAVLLAL LGTTWAEVWP PQLQEQAPMA GALNRKESFL LLSLHNRLRS
    61  WVQPPAADMR RLDWSDSLAQ LAQARAALCG IPTPSLASGL WRTLQVGWNM QLLPAGLASF
   121  VEVVSLWFAE GQRYSHAAGE CARNATCTHY TQLVWATSSQ LGCGRHLCSA GQTAIEAFVC
   181  AYSPGGNWEV NGKTIIPYKK GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG
   241  RLNISTCHCH CPPGYTGRYC QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH
   301  TCDLRIDGDC FMVSSEADTY YRARMKCQRK GGVLAQIKSQ KVQDILAFYL GRLETTNEVI
   361  DSDFETRNFW IGLTYKTAKD SFRWATGEHQ AFTSFAFGQP DNHGLVWLSA AMGFGNCVEL
   421  QASAAFNWND QRCKTRNRYI CQFAQEHISR WGPGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC18B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

kidney: 30 nTPM
testis: 4.1 nTPM
choroid plexus: 2.3 nTPM
retina: 2.1 nTPM
adrenal gland: 1.1 nTPM
cerebral cortex: 1.1 nTPM

Single-cell type

sertoli cells: 26 nCPM
proximal tubule cells: 20 nCPM
cone photoreceptor cells: 8.3 nCPM
retinal ganglion cells: 7.7 nCPM
retinal horizontal cells: 4 nCPM
esophageal apical cells: 3.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 6.8 nTPM
cerebellum: 5.8 nTPM
white matter: 5.1 nTPM
medulla oblongata: 4.6 nTPM
hypothalamus: 4.3 nTPM
spinal cord: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

polysaccharide binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC18B as an antibody target. Whether an autoantibody or antibody against CLEC18B could matter depends on whether native CLEC18B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC18B is annotated as secreted, so native CLEC18B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLEC18B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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