Seroatlas · Human Serome Atlas

DGCR2

Integral membrane protein DGCR2/IDD

Also known as: DGS-C, IDD, IDD_HUMAN, KIAA0163, LAN, SEZ-12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98153
Gene: DGCR2
Ensembl: ENSG00000070413
Chromosome: 22
Canonical length: 550 aa
Protein class: Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>P98153|DGCR2
     1  MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ CDGWATCEDE
    61  SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV NVAQPVRFSS FLGKCPTGWH
   121  HYEGTASCYR VYLSGENYWD AAQTCQRLNG SLATFSTDQE LRFVLAQEWD QPERSFGWKD
   181  QRKLWVGYQY VITGRNRSLE GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH
   241  FPTLRHHDLH SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG
   301  GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL VVSCISSFLI
   361  LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD YGPDGFGTGL TPLHLSDDGE
   421  GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP YEASIHPDSV FYDPADDDAF EPVEVSLPAP
   481  GDGGSEGALL RRLEQPLPTA GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR
   541  HSRSSLNTVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DGCR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

skin: 59 nTPM
cerebral cortex: 50 nTPM
esophagus: 45 nTPM
basal ganglia: 44 nTPM
hippocampal formation: 44 nTPM
cerebellum: 44 nTPM

Single-cell type

neutrophils: 231 nCPM
somatotrophs: 127 nCPM
alveolar cells type 1: 120 nCPM
oligodendrocyte progenitor cells: 106 nCPM
rod photoreceptor cells: 99 nCPM
neutrophil progenitors: 98 nCPM

Immune cell

neutrophil: 24 nTPM
eosinophil: 17 nTPM
total PBMC: 11 nTPM
classical monocyte: 10 nTPM
basophil: 9.5 nTPM
T-reg: 9.5 nTPM

Brain region

hypothalamus: 90 nTPM
cerebral cortex: 83 nTPM
amygdala: 77 nTPM
medulla oblongata: 77 nTPM
midbrain: 74 nTPM
thalamus: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

carbohydrate binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

VWFC domain
C-type lectin-like
Low-density lipoprotein (LDL) receptor class A repeat
C-type lectin-like/link domain superfamily
C-type lectin fold
Low-density lipoprotein (LDL) receptor class A, conserved site
LDL receptor-like superfamily
Low-density lipoprotein receptor domain class A
Lectin C-type domain
DGCR2-like, C-type lectin-like domain
Integral membrane protein DGCR2/IDD

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DGCR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

WWP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DGCR2 as an antibody target. Whether an autoantibody or antibody against DGCR2 could matter depends on whether native DGCR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DGCR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DGCR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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