Seroatlas · Human Serome Atlas

CD72

B-cell differentiation antigen CD72

Also known as: CD72_HUMAN, CD72b, LYB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P21854
Gene: CD72
Ensembl: ENSG00000137101
Chromosome: 9
Canonical length: 359 aa
Protein class: CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables transmembrane signaling receptor activity. Involved in negative regulation of B cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>P21854|CD72
     1  MAEAITYADL RFVKAPLKKS ISSRLGQDPG ADDDGEITYE NVQVPAVLGV PSSLASSVLG
    61  DKAAVKSEQP TASWRAVTSP AVGRILPCRT TCLRYLLLGL LLTCLLLGVT AICLGVRYLQ
   121  VSQQLQQTNR VLEVTNSSLR QQLRLKITQL GQSAEDLQGS RRELAQSQEA LQVEQRAHQA
   181  AEGQLQACQA DRQKTKETLQ SEEQQRRALE QKLSNMENRL KPFFTCGSAD TCCPSGWIMH
   241  QKSCFYISLT SKNWQESQKQ CETLSSKLAT FSEIYPQSHS YYFLNSLLPN GGSGNSYWTG
   301  LSSNKDWKLT DDTQRTRTYA QSSKCNKVHK TWSWWTLESE SCRSSLPYIC EMTAFRFPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

lymph node: 60 nTPM
spleen: 52 nTPM
tonsil: 47 nTPM
appendix: 19 nTPM
choroid plexus: 11 nTPM
small intestine: 7.9 nTPM

Single-cell type

b-cells: 89 nCPM
kupffer cells: 66 nCPM
cdc: 55 nCPM
macrophages: 46 nCPM
nk-cells: 42 nCPM
monocytes: 30 nCPM

Immune cell

naive B-cell: 413 nTPM
memory B-cell: 234 nTPM
myeloid DC: 20 nTPM
total PBMC: 15 nTPM
plasmacytoid DC: 11 nTPM
NK-cell: 9.4 nTPM

Brain region

choroid plexus: 5.1 nTPM
thalamus: 4.1 nTPM
medulla oblongata: 3 nTPM
cerebral cortex: 2.5 nTPM
pons: 2.2 nTPM
white matter: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.02
gnomAD missense Z: 0.39
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

C-type lectin-like
C-type lectin-like/link domain superfamily
C-type lectin fold
Lectin C-type domain
B-cell differentiation antigen CD72

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD72 as an antibody target. Whether an autoantibody or antibody against CD72 could matter depends on whether native CD72 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD72 is annotated at the cell surface, where native CD72 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD72 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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