Seroatlas · Human Serome Atlas

KLRG1

Killer cell lectin-like receptor subfamily G member 1

Also known as: 2F1, CLEC15A, KLRG1_HUMAN, MAFA, MAFA-L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96E93
Gene
KLRG1
Ensembl
ENSG00000139187
Chromosome
12
Canonical length
195 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q96E93|KLRG1
     1  MTDSVIYSML ELPTATQAQN DYGPQQKSSS SRPSCSCLVA IALGLLTAVL LSVLLYQWIL
    61  CQGSNYSTCA SCPSCPDRWM KYGNHCYYFS VEEKDWNSSL EFCLARDSHL LVITDNQEMS
   121  LLQVFLSEAF CWIGLRNNSG WRWEDGSPLN FSRISSNSFV QTCGAINKNG LQASSCEVPL
   181  HWVCKKCPFA DQALF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
9.8 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 9.8 nTPM
  • spleen: 8.3 nTPM
  • tonsil: 4.7 nTPM
  • appendix: 3.6 nTPM
  • gallbladder: 3.1 nTPM
  • bone marrow: 2.8 nTPM

Single-cell type

  • mast cells: 135 nCPM
  • t-cells: 98 nCPM
  • nk-cells: 72 nCPM
  • myonuclei: 57 nCPM
  • cardiomyocytes: 45 nCPM
  • oligodendrocyte progenitor cells: 33 nCPM

Immune cell

  • MAIT T-cell: 462 nTPM
  • gdT-cell: 392 nTPM
  • memory CD8 T-cell: 238 nTPM
  • naive CD8 T-cell: 148 nTPM
  • total PBMC: 100 nTPM
  • memory CD4 T-cell: 85 nTPM

Brain region

  • cerebellum: 14 nTPM
  • midbrain: 12 nTPM
  • white matter: 12 nTPM
  • hypothalamus: 12 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.78
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLRG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRG1 as an antibody target. Whether an autoantibody or antibody against KLRG1 could matter depends on whether native KLRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRG1 is annotated at the cell surface, where native KLRG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • They can also regulate specific humoral and cell-mediated immunity.

Canonical record: https://seroatlas.com/gene/KLRG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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