Seroatlas · Human Serome Atlas

REG1A

Lithostathine-1-alpha

Also known as: PSP, PSPS, PSPS1, PTP, REG, REG1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P05451
Gene: REG1A
Ensembl: ENSG00000115386
Chromosome: 2
Canonical length: 166 aa
Protein class: Plasma proteins, Predicted secreted proteins, Transporters
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>P05451|REG1A
     1  MAQTSSYFML ISCLMFLSQS QGQEAQTELP QARISCPEGT NAYRSYCYYF NEDRETWVDA
    61  DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SGTDDFNVWI GLHDPKKNRR WHWSSGSLVS
   121  YKSWGIGAPS SVNPGYCVSL TSSTGFQKWK DVPCEDKFSF VCKFKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REG1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 108,892 nTPM

Expression across tissuesHPA

Tissue

pancreas: 108,892 nTPM
duodenum: 7,152 nTPM
small intestine: 5,775 nTPM
stomach: 891 nTPM
rectum: 264 nTPM
appendix: 188 nTPM

Single-cell type

pancreatic acinar cells: 145,430 nCPM
paneth cells: 13,126 nCPM
enteric transient amplifying cells: 5,459 nCPM
gastric chief cells: 5,044 nCPM
enteric stem cells: 4,394 nCPM
enterocytes: 3,751 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REG1A as an antibody target. Whether an autoantibody or antibody against REG1A could matter depends on whether native REG1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REG1A is annotated as secreted, so native REG1A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label REG1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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