Seroatlas · Human Serome Atlas

CLEC1A

C-type lectin domain family 1 member A

Also known as: CLC1A_HUMAN, CLEC-1, CLEC1, MGC34328

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NC01
Gene: CLEC1A
Ensembl: ENSG00000150048
Chromosome: 12
Canonical length: 280 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q8NC01|CLEC1A
     1  MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTEH RAPSSTWRPV ALTLLTLCLV
    61  LLIGLAALGL LFFQYYQLSN TGQDTISQME ERLGNTSQEL QSLQVQNIKL AGSLQHVAEK
   121  LCRELYNKAG AHRCSPCTEQ WKWHGDNCYQ FYKDSKSWED CKYFCLSENS TMLKINKQED
   181  LEFAASQSYS EFFYSYWTGL LRPDSGKAWL WMDGTPFTSE LFHIIIDVTS PRSRDCVAIL
   241  NGMIFSKDCK ELKRCVCERR AGMVKPESLH VPPETLGEGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

thymus: 47 nTPM
placenta: 46 nTPM
lung: 28 nTPM
adipose tissue: 16 nTPM
breast: 15 nTPM
fallopian tube: 9.4 nTPM

Single-cell type

vascular endothelial cells: 130 nCPM
extravillous trophoblasts: 97 nCPM
migrating cytotrophoblasts: 76 nCPM
cytotrophoblasts: 69 nCPM
syncytiotrophoblasts: 59 nCPM
lymphatic endothelial cells: 31 nCPM

Immune cell

myeloid DC: 2.1 nTPM
neutrophil: 1.1 nTPM
classical monocyte: 0.9 nTPM
intermediate monocyte: 0.5 nTPM
non-classical monocyte: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

cerebellum: 12 nTPM
thalamus: 9 nTPM
medulla oblongata: 8.4 nTPM
pons: 8.1 nTPM
cerebral cortex: 7.6 nTPM
amygdala: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC1A as an antibody target. Whether an autoantibody or antibody against CLEC1A could matter depends on whether native CLEC1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC1A is annotated at the cell surface, where native CLEC1A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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