SELE

Protein identityUniProt · HPA

UniProt accession

P16581

Gene

SELE

Ensembl

ENSG00000007908

Chromosome

1

Canonical length

610 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>P16581|SELE
     1  MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN
    61  SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK
   121  DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC
   181  TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV
   241  ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK
   301  AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP
   361  VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN
   421  EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELHGS TQLECTSQGQ
   481  WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW
   541  SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD
   601  GSYQKPSYIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

52 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for SELE from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.86

gnomAD pLI

0

gnomAD missense Z

-0.13

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament-based process
• calcium-mediated signaling
• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
• inflammatory response
• leukocyte cell-cell adhesion
• leukocyte migration involved in inflammatory response
• leukocyte tethering or rolling
• phospholipase C-activating G protein-coupled receptor signaling pathway
• positive regulation of leukocyte migration
• positive regulation of leukocyte tethering or rolling
• positive regulation of receptor internalization
• regulation of inflammatory response
• response to cytokine
• response to interleukin-1
• response to lipopolysaccharide
• response to tumor necrosis factor

Molecular functions

• metal ion binding
• oligosaccharide binding
• phospholipase binding
• sialic acid binding
• transmembrane signaling receptor activity

Cellular components

• caveola
• clathrin-coated pit
• cortical cytoskeleton
• external side of plasma membrane
• extracellular space
• membrane raft
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Sushi/SCR/CCP domain
• EGF-like domain
• C-type lectin-like
• Selectin superfamily
• C-type lectin-like/link domain superfamily
• C-type lectin fold
• C-type lectin, conserved site
• Selectin, C-type lectin-like domain
• Sushi/SCR/CCP superfamily
• EGF-like domain
• Lectin C-type domain
• Sushi repeat (SCR repeat)

KeywordsUniProt

• Calcium
• Cell adhesion
• Cell membrane
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Lectin
• Membrane
• Metal-binding
• Repeat
• Signal
• Sushi
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SELE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PODXL2