Seroatlas · Human Serome Atlas

SUSD5

Sushi domain-containing protein 5

Also known as: KIAA0527, SUSD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60279
Gene
SUSD5
Ensembl
ENSG00000173705
Chromosome
3
Canonical length
629 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable hyaluronic acid binding activity. Predicted to be involved in Notch signaling pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

629 residues, UniProt reviewed canonical sequence.

>O60279|SUSD5
     1  MTAEGPSPPA RWHRRLPGLW AAALLLLGLP RLSVRADGKF FVLESQNGSQ GLQLEAARLS
    61  CKSRGAHLAS ADELRRVVQD CSFAVCTTGW LADGTLGTTV CSKGSGEQQI MRAVDVRIES
   121  NPVPGGTYSA LCIKDEEKPC GDPPSFPHTI LQGRTGLEMG DELLYVCAPG HIMGHRETAF
   181  TLLCNSCGEW YGLVQACGKD EAEAHIDYED NFPDDRSVSF RELMEDSRTE ADEDRGQGDS
   241  SEEAPKQDRL VSISVGRENI ARDKVFVPTT GLPGAGSSVP ADSPGSRLLQ KHLFWFPAEA
   301  FHKPGLEKEV DDDTKKQFSA GDNHSGVKLV PGEPETKVIY GNTDGPSGPF VGKNDSKAGD
   361  PVVSSSDESW LDGYPVTEGA WRKTEAEEEE DGDRGDGSVG LDENVLVTPD QPILVEVKKP
   421  KSSTLTPSEG MTHSSVLPSQ MLDVEALALR PVNASETEGI GDGDLTKYQS TLPWRFITEE
   481  SPMATLSYEL TSSTLEILTV NTVKQTPNHI PSTIMATTQP PVETTVPEIQ DSFPYLLSED
   541  FFGQEGPGPG ASEELHPTLE SCVGDGCPGL SRGPVIATIV TVLCLLLLLA GVGMVWGYRK
   601  CQHKSSVYKL NVGQRQARHY HQQIEMEKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUSD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
170 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 170 nTPM
  • cerebral cortex: 6.5 nTPM
  • seminal vesicle: 6 nTPM
  • cervix: 5.9 nTPM
  • hypothalamus: 5.3 nTPM
  • gallbladder: 5.1 nTPM

Single-cell type

  • vascular smooth muscle cells: 143 nCPM
  • oligodendrocyte progenitor cells: 114 nCPM
  • undifferentiated spermatogonia: 44 nCPM
  • retinal pigment epithelial cells: 34 nCPM
  • choroid plexus epithelial cells: 31 nCPM
  • melanocytes: 25 nCPM

Immune cell

  • naive B-cell: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 9.7 nTPM
  • cerebral cortex: 9.6 nTPM
  • choroid plexus: 9.4 nTPM
  • spinal cord: 8.3 nTPM
  • medulla oblongata: 7.6 nTPM
  • white matter: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUSD5 as an antibody target. Whether an autoantibody or antibody against SUSD5 could matter depends on whether native SUSD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUSD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUSD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SUSD5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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